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Klrb1c Gene Detail
 Symbol
Name
ID
Klrb1c
killer cell lectin-like receptor subfamily B member 1C
MGI:107538

Nomenclature History
Synonyms CD161, Ly-59, Ly55c, Ly59, Nk-1, NK-1.1, Nk-1.2, NK-RP1, Nk1, Nk1.1, NKR-P1, NKR-P1C, Nkrp1-c
Genetic Map
Chromosome 6
62.1 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 26)

Sequence Map
Chr6:128728507-128738598 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
Protein SuperFamily: killer cell lectin-like receptor subfamily B member 1
TreeFam: TF337735
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000030325 Ensembl Gene Model | MGI Sequence Detail 10092 C57BL/6J ± Kb
transcript NM_001159904 RefSeq | MGI Sequence Detail 2641 C57BL/6
polypeptide P27814 UniProt | EBI | MGI Sequence Detail 223 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Other(2)
This locus controls an antigen on natural killer cells. The a allele determines the Nk1.1 antigen in strains CE, C57BL/6, C57BR/cd, C57L, C58, DBA/1, MA/My, NZB, SJL, SM and B10.D2. The b allele determines the Nk1.2 antigen in strains CBA/J, BALB/c, C3H/He, A/J, DBA/2, LP and 129.
Polymorphisms RFLP(3) SNPs within 2kb(78 from dbSNP Build 128)   SNPs within 2kb including multiple locations(86)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process positive regulation of natural killer cell mediated cytotoxicity
Component external side of plasma membrane, integral to membrane...
Function binding, protein homodimerization activity...
External Resources: FuncBase
Expression cDNA source data(8)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(17) Genomic(8) cDNA(8) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030325
DoTS DT.110487325, DT.94126893
Consensus CDS Project CCDS39654.1
Entrez Gene 17059
International Mouse Knockout Project Status Klrb1c
Protein
domains
InterPro ID Description
IPR001304 C-type lectin
IPR002353 Type II antifreeze protein
IPR016186 C-type lectin-like
IPR016187 C-type lectin fold
Graphical View of Protein Domain Structure
References
(Earliest) J:5742 Glimcher L et al., "Identification of a cell-surface antigen selectively expressed on the natural killer cell." J Exp Med 1977 Jan 1;145(1):1-9
(Latest) J:144471 Shimizu K et al., "DC therapy induces long-term NK reactivity to tumors via host DC." Eur J Immunol 2009 Feb;39(2):457-68
All references(49)
Other
accession IDs 		MGD-MRK-12001, MGD-MRK-12044, MGD-MRK-12881, MGD-MRK-12883, MGD-MRK-36108, MGI:2141422, MGI:96879, MGI:97344
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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