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Ednra Gene Detail
 Symbol
Name
ID
Ednra
endothelin receptor type A
MGI:105923


Nomenclature History
Synonyms ET-AR, ETa, Gpcr10
Genetic Map
Chromosome 8
cytoband C2
 
Mapping data( 3)
Sequence Map
Chr8:80186930-80248363 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Protein SuperFamily: endothelin receptor
TreeFam: TF331292
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024406 VEGA Gene Model | MGI Sequence Detail 61434 C57BL/6J ± Kb
transcript NM_010332 RefSeq | MGI Sequence Detail 3643 C57BL/6
polypeptide Q61614 UniProt | EBI | MGI Sequence Detail 427 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes
All alleles(8) : Targeted, knock-out(2) Targeted, other(5) Gene trapped(1)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(276 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process G-protein coupled receptor protein signaling pathway, glucose transport...
Component integral to membrane, membrane...
Function endothelin receptor activity, G-protein coupled receptor activity...
External Resources: FuncBase
Expression Literature Summary: (20 records)
Data Summary: Assays (7)    Results (71)    Tissues (40)    Images (11)
Theiler Stages: 13,15,18,19,20,23,25,26,28
  Assay Type Assays   Results
      RT-PCR 2   16
      RNA in situ 3   42
      Northern blot 2   13
cDNA source data(12)
External Resources: GEO  ArrayExpress 
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(1) Other(3)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000031616
DoTS DT.101287404, DT.40143707, DT.484376
Consensus CDS Project CCDS22427.1
DFCI TC1577235, TC1621951
NIA Mouse Gene Index U029983, U029984
Entrez Gene 13617
VEGA Gene Model OTTMUSG00000024406
International Mouse Knockout Project Status Ednra
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR000499 Endothelin receptor
IPR002175 Endothelin A receptor
IPR017452 GPCR, rhodopsin-like superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:15563 Wilkie TM et al., "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors." Genomics 1993 Nov;18(2):175-84
(Latest) J:149166 Ruest LB et al., "Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism." Dev Biol 2009 Apr 1;328(1):94-108
All references(42)
Other
accession IDs
MGD-MRK-16350, MGD-MRK-33601, MGI:99570

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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