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Pou2af1 Gene Detail
 Symbol
Name
ID
Pou2af1
POU domain, class 2, associating factor 1
MGI:105086


Nomenclature History
Synonyms Bob-1, BOB.1, Bob1, OBF-1, OBF.1, OCA-B, OCAB
Genetic Map
Chromosome 9
Syntenic
 
Mapping data( 2)
Sequence Map
Chr9:51021795-51048184 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF332565
Sequences
Representative Sequences Length Strain/Species Flank
genomic 18985 NCBI Gene Model | MGI Sequence Detail 26390 C57BL/6J ± Kb
transcript NM_011136 RefSeq | MGI Sequence Detail 2566 C57BL/6
polypeptide Q64693 UniProt | EBI | MGI Sequence Detail 256 Not Applicable
For the selected sequences
All sequences(16)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(3)
Homozygotes for targeted null mutations exhibit reduced numbers of mature B cells, absence of germinal centers, and low serum levels of non-IgM immunoglobulins.
Polymorphisms SNPs within 2kb(193 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process regulation of transcription, transcription...
Component nucleus
Function DNA binding
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (3)    Results (78)    Tissues (71)    Images (3)
Theiler Stages: 17,21,23,28
  Assay Type Assays   Results
      RT-PCR 1   46
      RNA in situ 2   32
cDNA source data(30)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(33) Genomic(2) cDNA(30) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000032053
DoTS DT.490430
Consensus CDS Project CCDS23176.1
UniGene 897
DFCI TC1580604
NIA Mouse Gene Index U010474
Entrez Gene 18985
International Mouse Knockout Project Status Pou2af1
Protein
domains
InterPro ID Description
IPR015389 POU, class 2, associating factor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:30126 Pfisterer P et al., "Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1." J Biol Chem 1995 Dec 15;270(50):29870-80
(Latest) J:143921 Karnowski A et al., "Silencing and nuclear repositioning of the lambda5 gene locus at the pre-b cell stage requires Aiolos and OBF-1." PLoS ONE 2008;3(10):e3568
All references(41)
Other
accession IDs
MGD-MRK-32126

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory