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Ccr1 Gene Detail
 Symbol
Name
ID
Ccr1
chemokine (C-C motif) receptor 1
MGI:104618


Nomenclature History
Synonyms Cmkbr1, MIP-1 alphaR, Mip-1a-R
Genetic Map
Chromosome 9
71.6 cM, cytoband F
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr9:123876957-123883399 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ccr1 ± 2 cM)
Protein SuperFamily: chemokine receptor
TreeFam: TF330966
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12768 NCBI Gene Model | MGI Sequence Detail 6443 C57BL/6J ± Kb
transcript NM_009912 RefSeq | MGI Sequence Detail 2831 C57BL/6
polypeptide P51675 UniProt | EBI | MGI Sequence Detail 355 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(2)
Homozygotes for targeted null mutations exhibit altered trafficking and proliferation of myeloid progenitor cells, and impairments in granulomatous inflammation of the lung and neutrophil associated host defense.
Polymorphisms RFLP(2) SNPs within 2kb(44 from dbSNP Build 128)   SNPs within 2kb including multiple locations(52)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process G-protein coupled receptor protein signaling pathway, inflammatory response...
Component integral to membrane, membrane...
Function C-C chemokine receptor activity, G-protein coupled receptor activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (5)    Tissues (5)    Images (1)
Theiler Stages: 13,20
  Assay Type Assays   Results
      RNase protection 1   5
cDNA source data(15)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(15) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025804
DoTS DT.55209071
Consensus CDS Project CCDS23666.1
UniGene 274927
DFCI TC1582465
NIA Mouse Gene Index U031484
Entrez Gene 12768
International Mouse Knockout Project Status Ccr1
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR000355 Chemokine receptor
IPR002236 C-C chemokine receptor, type 1
IPR017452 GPCR, rhodopsin-like superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:27219 Gao JL et al., "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." J Biol Chem 1995 Jul 21;270(29):17494-501
(Latest) J:152548 Seki E et al., "CCR1 and CCR5 promote hepatic fibrosis in mice." J Clin Invest 2009 Jul;119(7):1858-70
All references(63)
Other
accession IDs
MGD-MRK-26055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory