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Grb10 Gene Detail
 Symbol
Name
ID
Grb10
growth factor receptor bound protein 10
MGI:103232

Nomenclature History
Synonyms 5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207
Genetic Map
Chromosome 11
8.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr11:11830511-11938686 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Grb10 ± 2 cM)
TreeFam: TF317511
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005165 VEGA Gene Model | MGI Sequence Detail 108176 C57BL/6J ± Kb
transcript NM_010345 RefSeq | MGI Sequence Detail 5015 C57BL/6
polypeptide Q60760 UniProt | EBI | MGI Sequence Detail 621 Not Applicable
For the selected sequences
All sequences(42)
Alleles
and
phenotypes 		All alleles(35) : Targeted, knock-out(2) Gene trapped(33)
Maternal transmission of a mutant allele results in both fetal and placental overgrowth. Disproportionate overgrowth of the liver is observed. Paternal transmission of an allele lacking the differentially methylated region results in growth retardation.
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(312 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process insulin-like growth factor receptor signaling pathway, negative regulation of glucose import...
Component cytosol
Function insulin receptor binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (25 records)
Data Summary: Assays (12)    Results (51)    Tissues (26)    Images (18)
Theiler Stages: 13,15,17,20,21,22,24,26,28
  Assay Type Assays   Results
      RT-PCR 8   30
      RNA in situ 4   21
cDNA source data(31)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(44) Genomic(2) cDNA(34) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000020176
DoTS DT.101308184, DT.101404550, DT.101404554, DT.495965, DT.97361289
Consensus CDS Project CCDS24440.1
DFCI TC1572295, TC1656656, TC1685243, TC1734988
NIA Mouse Gene Index U032516
Entrez Gene 14783
VEGA Gene Model OTTMUSG00000005165
International Mouse Knockout Project Status Grb10
Protein
domains
InterPro ID Description
IPR000159 Ras-association
IPR000980 SH2 motif
IPR001849 Pleckstrin homology
IPR011993 Pleckstrin homology-type
IPR015042 BPS (Between PH and SH2) domain
Graphical View of Protein Domain Structure
References
(Earliest) J:24927 Ooi J et al., "The cloning of Grb10 reveals a new family of SH2 domain proteins." Oncogene 1995 Apr 20;10(8):1621-30
(Latest) J:153616 Gabory A et al., "H19 acts as a trans regulator of the imprinted gene network controlling growth in mice." Development 2009 Oct;136(20):3413-21
All references(51)
Other
accession IDs 		MGD-MRK-24105, MGI:1915227, MGI:2144128
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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