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Zbtb16 Gene Detail
 Symbol
Name
ID
Zbtb16
zinc finger and BTB domain containing 16
MGI:103222


Nomenclature History
Synonyms Green's luxoid, PLZF, Zfp145
Genetic Map
Chromosome 9
23.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 22)

Sequence Map
Chr9:48462416-48644050 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Zbtb16 ± 2 cM)
TreeFam: TF350825
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000066687 Ensembl Gene Model | MGI Sequence Detail 181635 C57BL/6J ± Kb
transcript NM_001033324 RefSeq | MGI Sequence Detail 5114 C57BL/6
polypeptide NP_001028496 RefSeq | MGI Sequence Detail 673 C57BL/6
For the selected sequences
All sequences(21)
Alleles
and
phenotypes
All alleles(4) : Targeted, knock-out(1) Spontaneous(2) Chemically induced(1)
Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.
Polymorphisms SNPs within 2kb(1099 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process anterior/posterior pattern formation, embryonic hindlimb morphogenesis...
Component nucleus, transcriptional repressor complex...
Function DNA binding, metal ion binding...
External Resources: FuncBase
Expression Literature Summary: (24 records)
Data Summary: Assays (8)    Results (152)    Tissues (133)    Images (37)
Theiler Stages: 11,13,17,18,21,22,28
  Assay Type Assays   Results
      RNA in situ 6   142
      Immunohistochemistry 2   10
cDNA source data(12)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(18) cDNA(13) Primer pair(4) Other(1) Antibodies(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000066687
DoTS DT.101309779, DT.101360589, DT.40136349, DT.40175915
Consensus CDS Project CCDS23158.1
DFCI TC1601528, TC1653003
NIA Mouse Gene Index U081113
Entrez Gene 235320
International Mouse Knockout Project Status Zbtb16
Protein
domains
InterPro ID Description
IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2-type
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR013087 Zinc finger, C2H2-type/integrase, DNA-binding
IPR015880 Zinc finger, C2H2-like
References
(Earliest) J:13069 Green MC, "Luxoid, a new hereditary leg and foot abnormality in the house mouse." J Hered 1955;46():91-99
(Latest) J:153481 Weng J et al., "Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice." Alcohol Clin Exp Res 2009 Aug;33(8):1409-16
All references(57)
Other
accession IDs
MGD-MRK-11929, MGD-MRK-24092, MGI:2143075, MGI:96851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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