Symbol
Name
ID
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Synonyms
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A beta, Abeta, H-2Ab, H2-Ab, I-Ab, I-Abeta, Ia-2, Ia2, IAb, Rmcs1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
|
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Sequences
|
All sequences(89)
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Alleles
and
phenotypes
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All alleles(5) :
Targeted, knock-out(2)
Targeted, other(2)
Spontaneous(1)
| Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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Polymorphisms
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All PCR and RFLP(10) :
PCR(1)
RFLP(9)
SNPs within 2kb(93 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (3 records)
Data Summary:
Assays (1)
Results (2)
Tissues (1)
Theiler Stages: 26
| |
Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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2 |
cDNA source data(151)
External Resources:
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(188)
Genomic(30)
cDNA(152)
Primer pair(4)
Other(2)
Microarray probesets(4)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000073421 |
| DoTS |
DT.101125647, DT.101382213, DT.533732, DT.94191527 |
| Consensus CDS Project |
CCDS37583.1 |
| UniGene |
254067 |
| PDB |
1D9K, 1F3J, 1IAK, 1IAO, 1JL4, 1LNU, 1MUJ, 2IAD, 3C5Z, 3C60, 3C6L, 3CUP |
| NIA Mouse Gene Index |
U017850 |
| Entrez Gene |
14961 |
| International Mouse Knockout Project Status |
H2-Ab1 |
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Protein
domains
|
| InterPro ID |
Description |
| IPR000353 |
MHC class II, beta chain, N-terminal |
| IPR003006 |
Immunoglobulin/major histocompatibility complex, conserved site |
| IPR003597 |
Immunoglobulin C1-set |
| IPR007110 |
Immunoglobulin-like |
| IPR011162 |
MHC classes I/II-like antigen recognition protein |
| IPR013783 |
Immunoglobulin-like fold |
| IPR014745 |
MHC class II, alpha/beta chain, N-terminal |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:5527
Shreffler DC et al.,
"The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization."
Adv Immunol 1975;20():125-95
(Latest)
J:155694
Lawson VJ et al.,
"Early growth response 2 regulates the survival of thymocytes during positive selection."
Eur J Immunol 2010 Jan;40(1):232-41
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All references(461)
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Other
accession IDs
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MGD-MRK-10378, MGD-MRK-10491, MGD-MRK-11045, MGD-MRK-11050, MGD-MRK-23932, MGI:1890696, MGI:2146934
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Analysis Tools
MGI BioMart
