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Human Disease and Mouse Model Detail
Human Disease

Term: Leukemia, Chronic Myeloid; CML
OMIM ID: 608232

Synonyms Leukemia, Chronic Myelogenous
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Dok1 DOK1
Dok2 DOK2
Sipa1 SIPA1
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Bcr BCR
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(BCR/ABL1)5Hhi   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Ly6a-BCR/ABL1)IS1AIsg
Tg(Ly6a-BCR/ABL1)IS1BIsg
Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg
Tg(Tal1-tTA)19Dgt
Tg(tetO-BCR/ABL1)2Dgt

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Dok1tm1Ppp/Dok1+
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok1tm1Ppp/Dok1tm1Ppp
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
  129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp J:95334
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
  B6.129-Dok1tm1Yyam Dok2tm1Yyam J:95335
Dok1tm1Yyam/Dok1tm1Yyam
Tg(BCR/ABL1)5Hhi/0
  involves: C57BL/6 J:95335
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
  involves: C57BL/6 J:95335
Dok2tm1Ppp/Dok2tm1Ppp
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok2tm1Ppp/Dok2+
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
  involves: C57BL/6 J:95335
Sipa1tm1Nm/Sipa1tm1Nm   involves: 129P2/OlaHsd * C57BL/6 J:97239
Sipa1tm1Nm/Sipa1+   involves: 129P2/OlaHsd * C57BL/6 J:97239
Models involving transgenes or other mutation types.2
Dok1tm1Ppp/Dok1+
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok1tm1Ppp/Dok1tm1Ppp
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok1tm1Yyam/Dok1tm1Yyam
Tg(BCR/ABL1)5Hhi/0
  involves: C57BL/6 J:95335
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
  involves: C57BL/6 J:95335
Dok2tm1Ppp/Dok2tm1Ppp
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok2tm1Ppp/Dok2+
Tg(BCR/ABL1)5Hhi/0
  involves: 129S1/Sv J:95334
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
  involves: C57BL/6 J:95335
Tg(Ly6a-BCR/ABL1)IS1BIsg/0   involves: C57BL/6J * CBA J:144382
Tg(Ly6a-BCR/ABL1)IS1AIsg/0   involves: C57BL/6J * CBA J:144382
Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg/0   involves: C57BL/6J * CBA J:144382
Tg(tetO-BCR/ABL1)2Dgt/0
Tg(Tal1-tTA)19Dgt/0
  involves: C57BL/6 * DBA/2 * FVB/N J:96511

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory