Human Disease and Mouse Model Detail

Human Disease

Term: Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related
OMIM ID: 607485

Synonyms

Frontotemporal Dementia, Ubiquitin-Positive; FTDU; Frontotemporal Dementia with Tdp43 Inclusions, Grn-Related; Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions; FTLDU; Ftld-Tdp, Grn-Related

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Grn

GRN

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Transgenes and
other mutation types

Tg(Camk2a-Tardbp)#Ckjs		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Prnp-TARDBP)3cPtrc
Tg(Thy1-TARDBP*)BOddo

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models involving transgenes or other mutation types.¹
Tg(Camk2a-Tardbp)#Ckjs/Tg(Camk2a-Tardbp)#Ckjs		FVB/N-Tg(Camk2a-Tardbp)#Ckjs	J:163612
Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc		C57BL/6-Tg(Prnp-TARDBP)3cPtrc	J:163231
Tg(Thy1-TARDBP*)BOddo/0		C57BL/6-Tg(Thy1-TARDBP*)BOddo	J:180165

¹Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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