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Human Disease and Mouse Model Detail
Human Disease

Term: Patent Ductus Arteriosus
OMIM ID: 607411

Synonyms PDA; PDA1
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Hpgd HPGD
Jag1 JAG1
Myocd MYOCD
Ptger4 PTGER4
Ptgs1 PTGS1
Ptgs2 PTGS2
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.1
Hpgdtm1Bhk/Hpgdtm1Bhk   involves: 129P2/OlaHsd J:74466
Jag1tm1Grid/Jag1tm2Grid
Tg(Tagln-cre)1Her/0		 2 involves: 129S1/Sv * C57BL/6 * SJL J:166769
Myocdtm1Msp/Myocdtm1Msp
Tg(Wnt1-cre)11Rth/0		 2 involves: 129/Sv * C57BL/6 * CBA J:131288
Myocdtm1Msp/Myocdtm1Msp
Tg(Pax3-cre)1Joe/0		 2 involves: 129/Sv * C57BL/6 * SJL J:131288
Ptger4tm1Aic/Ptger4tm1Aic   involves: 129P2/OlaHsd * C57BL/6 J:47618
Ptger4tm1Bhk/Ptger4tm1Bhk   involves: 129P2/OlaHsd * 129S/SvEv J:44108
Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2tm1Unc		   involves: 129P2/OlaHsd * C57BL/6J J:67208

1The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
2Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory