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Human Disease and Mouse Model Detail
Human Disease

Term: Alzheimer Disease 4
OMIM ID: 606889

Synonyms Ad4; Alzheimer Disease, Familial, 4
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Psen2 PSEN2
  mousehuman...both mouse and human orthologous genes.
     
Psen1 PSEN1
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Apoe APOE
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(APP695)3Dbo   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(PSEN1)5Dbo
Tg(PSEN1dE9)S9Dbo

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0
3 involves: C57BL/6 * CBA J:90685
Models involving transgenes or other mutation types.2
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
  involves: C3H/HeJ * C57BL/6J J:123534
Tg(APP695)3Dbo/0   B6.C3-Tg(APP695)3Dbo J:109847
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
  involves: C3H/HeJ * C57BL/6J J:43788

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.
3Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory