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Human Disease and Mouse Model Detail
Human Disease

Term: Maturity-Onset Diabetes of the Young; MODY
OMIM ID: 606391

Synonyms Mason-Type Diabetes
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Ins1 none identified
Ins2 INS
Mafa MAFA
Pdx1 PDX1
Tgm2 TGM2
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.1
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja		   involves: 129S2/SvPas J:40377, J:77595
Ins2Akita/Ins2+   C57BL/6-Ins2Akita J:40063
Ins2Akita/Ins2+   C57BL/6-Ins2Akita/J J:99412
Mafatm1Staka/Mafatm1Staka   involves: ICR J:99126
Pdx1tm1Ted/Pdx1+   involves: 129P2/OlaHsd J:48516, J:82969
Tgm2tm1Gml/Tgm2tm1Gml   involves: 129X1/SvJ * C57BL/6 J:75566, J:78633, J:82489

1The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory