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Human Disease and Mouse Model Detail
Human Disease

Term: Cerebral Amyloid Angiopathy, App-Related
OMIM ID: 605714

Synonyms Amyloidosis, Cerebroarterial, App-Related; Amyloidosis, Hereditary, with Cerebral Hemorrhage, Dutch Variant; HCHWAD; Cerebral Amyloid Angiopathy, App-Related, Arctic Variant; Cerebral Amyloid Angiopathy, App-Related, Dutch Variant; Cerebral Amyloid Angiopathy, App-Related, Flemish Variant; Cerebral Amyloid Angiopathy, App-Related, Iowa Variant; Cerebral Amyloid Angiopathy, App-Related, Italian Variant
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Abcc1 ABCC1
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
App APP
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Thy1-APP)3Somm   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Thy1-AppDutch)#Jckr
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Tg(Thy1-BACE1)54/4Ppa
Tg(Thy1-MAPT)183Gotz
Tg(Thy1-PSEN1*G384A)45Jckr

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0
  FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr J:178230
Models involving transgenes or other mutation types.2
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0
  FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr J:178230
Tg(Thy1-APP)3Somm/0   involves: C57BL/6J * DBA/2 J:67583
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-BACE1)54/4Ppa/0
  involves: C57BL/6 J:162531
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-PSEN1*G384A)45Jckr/0
  involves: C57BL/6 * C57BL/6J * DBA/2 J:92796
Tg(Thy1-AppDutch)#Jckr/0   involves: C57BL/6J J:92796, J:162531
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0
  B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz J:154968
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0   C57BL/6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz J:165986

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory