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Human Disease and Mouse Model Detail
Human Disease

Term: Abdominal Obesity-Metabolic Syndrome
OMIM ID: 605552

Synonyms AOMS1
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
a ASIP
Apoe APOE
Ctf1 CTF1
Cyp19a1 CYP19A1
Gucy2c GUCY2C
Neil1 NEIL1
Pparg PPARG
Sirt3 SIRT3
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Mttp MTTP
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Fabp4-Hsd11b1)7Jesf   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Ay/a
Apoetm1Unc/Apoetm1Unc
  involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl J:177084
Apoetm1Unc/Apoetm1Unc
Cyp19a1tm1Esi/Cyp19a1tm1Esi
  involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 J:184647
Ctf1tm1Msd/Ctf1tm1Msd   B6.Cg-Ctf1tm1Msd J:176727
Gucy2ctm1Gar/Gucy2ctm1Gar   B6.129S6-Gucy2ctm1Gar J:178241
Neil1tm1Rsld/Neil1tm1Rsld   involves: 129S1/Sv * C57BL/6 J:106077
Ppargtm1Lja/Pparg+   involves: 129S1/Sv * 129X1/SvJ J:98786
Sirt3tm1.1Fwa/Sirt3tm1.1Fwa   involves: 129S6/SvEvTac J:178653
Models involving transgenes or other mutation types.2
Tg(Fabp4-Hsd11b1)7Jesf/0   FVB-Tg(Fabp4-Hsd11b1)7Jesf J:107046

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory