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Human Disease and Mouse Model Detail
Human Disease

Term: Cataract, Autosomal Dominant
OMIM ID: 604219

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Acc none identified
Alm none identified
Apo none identified
Apoca none identified
Cat2 none identified
Cat4 none identified
Ccw none identified
Coc none identified
Cryga CRYGA
Crygb CRYGB
Cryge none identified
Crygs CRYGS
Enc none identified
Iac none identified
Idc none identified
Lim2 LIM2
Mip MIP
Nuca none identified
Pax6 PAX6
Tcm none identified
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Transgenes and
other mutation types
Tg(CRYBB1-CRYGC*)#Jfhe   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Lim2*G15V)1Rlc

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.1
Acc/Acc+   involves: 101 * C3H J:9528
Alm/Alm+   involves: 101 * C3H J:9528
Apo/Apo+   involves: 101 * C3H J:9528
Apoca/Apoca+   involves: 101 * C3H J:9528
Cat2no2/Cat2+   DBA/2 J:16569
Cat4Apcat1-2/Cat4+   involves: 101 * C3H J:6686, J:9528
Cat4Apcat1-3/Cat4+   involves: 101 * C3H J:9528
Cat4Apcat1-4/Cat4+   involves: 101 * C3H J:1598
Ccw/Ccw+   involves: unpedigreed stock J:34877, J:66649
Coc/Coc+   involves: 101 * C3H * C57BL/6 J:9528
Coc/Coc   involves: 101 * C3H * C57BL/6 J:9528
Cryga1Neu/Cryga+   involves: 101 * C3H J:21950
CrygbNop/Crygb+   Not Specified J:7589
CrygbNop/CrygbNop   Not Specified J:7589
CrygbS11R/CrygbS11R   A/J-CrygbS11R J:132502
CrygbS11R/Crygb+   A/J-CrygbS11R J:132502
CrygeAey1/Cryge+   C3HeB/FeJ J:67888
CrygeAey1/CrygeAey1   C3HeB/FeJ J:67888
CrygeElo/Cryge+   involves: C57BL/6JNga J:15383
Crygenz/Cryge+   involves: 101 * C3H * C57BL/6 J:6686
Crygenz/Cryge+   involves: 101 * C3H J:9528
Crygenz/Crygenz   involves: 101 * C3H * C57BL/6 J:6686
Cryget/Cryge+   involves: 102/El * C3H/El * T-stock J:9528
Cryget/Cryget   involves: 102/El * C3H/El * T-stock J:9528
CrygsOpj/CrygsOpj   involves: 102 * C3H/He * T STOCK J:34877, J:68109
CrygsOpj/Crygs+   involves: 102 * C3H/He * T STOCK J:34877, J:68109
Crygsrncat/Crygsrncat   Kunming J:77271
Enc/Enc+   involves: 101 * C3H J:9528
Iac/Iac+   involves: 101 * C3H J:9528
Idc/Idc+   involves: 101 * C3H J:9528
Lim2To3/Lim2To3   involves: 102 * C3H/He * T STOCK J:46338
Lim2To3/Lim2+   involves: 102 * C3H/He * T STOCK J:46338
MipCat-Fr/MipCat-Fr   involves: A/J J:31574
MipCat-Lop/Mip+   involves: STOCK Rb(6.15)1Ald J:31574
MipHfi/Mip+   involves: 101 * C3H J:14285
MipHfi/MipHfi   involves: 101 * C3H J:14285
Nuca/Nuca+   involves: 101 * C3H J:9528
Pax6132-14Neu/Pax6+   involves: 101 * C3H J:6686
Tcm/Tcm+   involves: 101 * C3H J:9528
Models involving transgenes or other mutation types.2
Tg(CRYBB1-CRYGC*)#Jfhe/?   involves: FVB/N J:181433
Tg(Lim2*G15V)1Rlc/0   involves: C57BL/6 * SJL J:100078
Tg(Lim2*G15V)1Rlc/Tg(Lim2*G15V)1Rlc   involves: C57BL/6 * SJL J:100078

1The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
2Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory