Human Disease and Mouse Model Detail

Human Disease

Term: Dermatitis, Atopic
OMIM ID: 603165

Synonyms

ATOD

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Casp8	CASP8
Nfkbia	NFKBIA
Nfkbiz	NFKBIZ
Noa	none identified
Sharpin	SHARPIN
Traf3ip2	TRAF3IP2
Trpv3	TRPV3

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Transgenes and
other mutation types

Tg(CD2-Stat6V625AT626A)78Mhk		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(KRT5-rtTA)1Glk
Tg(KRT5-tTA)1216Glk
Tg(tetO/CMV-Tslp)#Sfz
Tg(tetO-Il13)1Tazh

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.¹
Casp8^tm1Hed/Casp8^tm1Hed Tg(KRT14-cre)1Efu/0	3	Not Specified	J:167299
Nfkbia^tm1Stw/Nfkbia^tm1Stw		involves: 129S1/Sv	J:32527
Nfkbiz^tm1Mamo/Nfkbiz^tm1Mamo		involves: 129S7/SvEvBrd	J:95040
Noa/Noa⁺		NOA	J:43274
Sharpin^cpdm/Sharpin^cpdm		C57BL/KaLawRij-Sharpin^cpdm	J:14539, J:31745, J:116833
Traf3ip2^adjm/Traf3ip2^adjm		AK.KOR-Traf3ip2^adjm	J:162859
Traf3ip2^adjm/Traf3ip2^adjm		A.KOR-Traf3ip2^adjm	J:162859
Traf3ip2^adjm/Traf3ip2^adjm		KOR-Traf3ip2^adjm	J:162859
Traf3ip2^adjm/Traf3ip2^adjm		C.KOR-Traf3ip2^adjm	J:162859
Traf3ip2^adjm/Traf3ip2^adjm		B6.KOR-Traf3ip2^adjm	J:162859
Trpv3^Nh/Trpv3⁺		DS	J:42153
Models involving transgenes or other mutation types.²
Tg(CD2-Stat6V625AT626A)78Mhk/0		involves: C3H * C57BL/6	J:160119
Tg(KRT5-rtTA)1Glk/0 Tg(tetO/CMV-Tslp)#Sfz/0		involves: C3H * C57BL/6 * FVB/N	J:100506
Tg(KRT5-tTA)1216Glk/0 Tg(tetO-Il13)1Tazh/0		B6.Cg-Tg(KRT5-tTA)1216Glk Tg(tetO-Il13)1Tazh	J:150232

¹The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
²Models involving transgenes or other mutation types may also appear in other sections of the table.
³Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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