Human Disease and Mouse Model Detail

Human Disease

Term: Toll-Like Receptor 4; TLR4
OMIM ID: 603030

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Tlr4

TLR4

...both mouse and human orthologous genes.

Apoe

APOE

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Apoe^tm1Unc/Apoe^tm1Unc Tlr4^tm1Aki/Tlr4^tm1Aki		involves: 129P2/OlaHsd * C57BL/6	J:91481
Tlr4^Lps-d/Tlr4^Lps-d		involves: C3H/HeJ	J:5721, J:51522, J:96356
Tlr4^lps-del/Tlr4^lps-del		C57BL/10ScCr	J:51522, J:88996, J:93263, J:97819
Tlr4^tm1Aki/Tlr4^tm1Aki		involves: 129P2/OlaHsd * C57BL/6J	J:98224
Tlr4^tm1Aki/Tlr4^tm1Aki		involves: 129P2/OlaHsd	J:53519

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/03/2013 MGI 5.12