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Human Disease and Mouse Model Detail
Human Disease

Term: Obesity
OMIM ID: 601665

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Adrb2 ADRB2
Adrb3 ADRB3
Mc4r MC4R
Pomc POMC
Sim1 SIM1
  mousehuman...both mouse and human orthologous genes.
     
a ASIP
Adrb1 ADRB1
Alms1 ALMS1
Angptl6 ANGPTL6
Ankrd26 ANKRD26
Ar AR
Bbs1 BBS1
Bbs4 BBS4
Cpe CPE
Gpr12 GPR12
Hlb228 none identified
Kdm3a KDM3A
Lep LEP
Lepr LEPR
Mc3r MC3R
Mkks MKKS
Ncoa1 NCOA1
Neil1 NEIL1
Nmf15 none identified
Npy1r NPY1R
Pcsk1 PCSK1
Plscr3 PLSCR3
Prlh PRLH
Prox1 PROX1
Rsc1a1 RSC1A1
Sim2 SIM2
Tub TUB
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Agrp AGRP
Cartpt CARTPT
Enpp1 ENPP1
Ghrl GHRL
Nr0b2 NR0B2
Pparg PPARG
Ppargc1b PPARGC1B
Pyy PYY
Sdc3 SDC3
Ucp1 UCP1
Ucp3 UCP3
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Crh)227.1Pbl   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Timo

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Adrb1tm1Bkk/Adrb1tm1Bkk
Adrb2tm1Bkk/Adrb2tm1Bkk
Adrb3tm1Lowl/Adrb3tm1Lowl		   involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N J:79309
Mc3rtm1Lvp/Mc3rtm1Lvp
Mc4rtm1Dhu/Mc4rtm1Dhu		   involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J J:64365
Mc4rtm1Dhu/Mc4rtm1Dhu   involves: 129S4/SvJae * C57BL/6J J:38224
Pomctm1Sora/Pomctm1Sora   involves: 129S2/SvHsd * 129S6/SvEvTac J:89244
Sim1tm1Fan/Sim1+   involves: 129/Sv * C57BL/6 J:70586
Sim1tm1Fan/Sim1+
Sim2tm1Fan/Sim2+		   involves: 129/Sv * C57BL/6 J:76787
Models with phenotypic similarity to human disease where etiologies are distinct.2
Aiy/Aiy   C3H/HeJ-Aiy J:30922
Aiy/A   C3H/HeJ-Aiy J:30922
Avy/a   involves: C3H/HeJ * C57BL/6 J:13142, J:117156
Ay/A   involves: C57BL/6 J:131039
Alms1bbb/Alms1bbb   C57BL/6JSfdAnu-Alms1bbb/Apb J:104190
Alms1Gt(XH152)Byg/Alms1Gt(XH152)Byg   involves: 129P2/OlaHsd * C57BL/6J J:100403
Angptl6tm1Yo/Angptl6tm1Yo   involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:97552
Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg   involves: 129P2/OlaHsd * C57BL/6 J:130984
Artm1Ska/Y
Tg(CMV-cre)1Ipc/?		 4 involves: C57BL/6 * CBA J:85484
Bbs1Gt1Nk/Bbs1Gt1Nk   involves: 129S7/SvEvBrd * C57BL/6J J:92950
Bbs4Gt1Nk/Bbs4Gt1Nk   involves: 129S7/SvEvBrd * C57BL/6J J:92950
Cpefat/Cpefat   HRS/J J:10872, J:13651
Cpefat/Cpefat   BKSChpLt.HRS-Cpefat/J J:10872
Gpr12tm1Dgen/Gpr12tm1Dgen   B6.129P2-Gpr12tm1Dgen J:111942
Hlb228/?   B6;129 J:82961
Kdm3atm1.1Yzha/Kdm3atm1.1Yzha   B6.129P2-Kdm3atm1.1Yzha J:147295
Lepm1Btlr/Lepm1Btlr   C57BL/6J-Lepm1Btlr J:189953
Lepob/Lepob   D2.B6-Lepob J:78850
Lepob/Lepob   B6.Cg-Lepob/J J:103063, J:104171
Leprbrta/Leprbrta   C57BL/6JSfdAnu-Leprbrta/Apb J:104190
LeprDb-2Btlr/LeprDb-2Btlr   C57BL/6J-LeprDb-2Btlr J:133633
Leprdb-3J/Leprdb-3J   129P3/J-Leprdb-3J/J J:6337
LeprDb-Btlr/LeprDb-Btlr   C57BL/6J-LeprDb-Btlr J:133632
Leprdb-Pas/Leprdb-Pas   DW/Pas J:31095
Leprdb/Leprdb   FVB.BKS-Leprdb J:78850
Leprdb/Leprdb   BKS.Cg-Dock7m +/+ Leprdb/J J:6323
Leprdb/Leprdb   B6.Cg-Dock7m +/+ Leprdb/J J:18161, J:82234, J:103063
Leprdb/Leprdb   C57BLKS/J J:96047, J:104790, J:106871
Leprm3Btlr/Leprm3Btlr   C57BL/6J-Leprm3Btlr J:140985
Leprtm1.1Chua/Leprtm1.1Chua   involves: 129 * C57BL/6 J:94019
Leprtm1.2Chua/Leprtm1.2Chua   involves: 129 * C57BL/6J * FVB/N J:106354
Leprtm1.2Chua/Leprtm1.2Chua   involves: 129 * C57BL/6 J:94019
Leprtm1Chua/Leprtm1Chua   involves: 129 * C57BL/6 J:94019
Leprtm1Mgmj/Leprtm1Mgmj   B6.129-Leprtm1Mgmj J:82334
Leprtm1Yli/Leprtm1Yli   B6.129-Leprtm1Yli J:142218
Leprtm2Yli/Leprtm2Yli   B6.129-Leprtm2Yli J:142218
Mc3rtm1Cone/Mc3rtm1Cone   involves: 129S4/SvJae * C57BL/6J J:78132
Mc3rtm1Cone/Mc3r+   involves: 129S4/SvJae * C57BL/6J J:78132
Mkkstm1Vcs/Mkkstm1Vcs   either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) J:99276
Ncoa1tm1.1Hkaw/Ncoa1tm1.1Hkaw   B6.Cg-Ncoa1tm1.1Hkaw J:111490
Neil1tm1Rsld/Neil1+   either: B6.129S1-Neil1tm1Rsld or (involves: 129S1/Sv * C57BL/6) J:106077
Nmf15/Nmf15+   C57BL/6J-Nmf15/J J:82238
Npy1rtm1Tped/Npy1rtm1Tped   B6.129P2-Npy1rtm1Tped J:87424
Pcsk1N222D/Pcsk1N222D   C57BL/6-Pcsk1N222D J:109531
Plscr3tm1Sims/Plscr3tm1Sims   129S5/SvEvBrd J:92404
Prlhtm1Taon/Prlhtm1Taon   B6N.129X1-Prlhtm1Taon J:144729
Prox1tm1Gco/Prox1+   involves: 129S1/Sv * 129X1/SvJ * NMRI J:102652
Rsc1a1tm1Koep/Rsc1a1tm1Koep   B6.129-Rsc1a1tm1Koep J:95148
Tubtub/Tubtub   C57BL/6J-Tubtub J:13772
Tubtub/Tubtub   B6(Cg)-Tubtub/J J:32415
Models involving transgenes or other mutation types.3
Tg(Crh)227.1Pbl/0   C57BL/6 J:92996
Timo/Timo   either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ) J:127183
Timo/Timo+   either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ) J:127183

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory