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Human Disease and Mouse Model Detail
Human Disease

Term: Leukemia, Acute Myeloid; AML
OMIM ID: 601626

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Cebpa CEBPA
Flt3 FLT3
  mousehuman...both mouse and human orthologous genes.
     
Arid4a ARID4A
Arid4b ARID4B
Crebbp CREBBP
Ctsg CTSG
Mll1 MLL
Nr4a1 NR4A1
Nr4a3 NR4A3
Sfpi1 SPI1
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Arhgef12 ARHGEF12
Cbfb CBFB
Chic2 CHIC2
Etv6 ETV6
Gata2 GATA2
Gmps GMPS
Jak2 JAK2
Kit KIT
Lpp LPP
Mlf1 MLF1
Mllt10 MLLT10
Npm1 NPM1
Nsd1 NSD1
Nup214 NUP214
Picalm PICALM
Runx1 RUNX1
Sh3gl1 SH3GL1
Tert TERT
Whsc1l1 WHSC1L1
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Cebpatm8.1Nerl/Cebpatm8.1Nerl   involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 J:136134
Flt3tm1Dgg/Flt3+
Mll1tm1Clgr/Mll1+
  involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J J:189096
Flt3tm1Dgg/Flt3tm1Dgg
Mll1tm1Clgr/Mll1+
  involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J J:189096
Models with phenotypic similarity to human disease where etiologies are distinct.2
Arid4atm1Alb/Arid4atm1Alb   involves: 129S7/SvEvBrd J:141004
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
  involves: 129S7/SvEvBrd J:141004
Crebbptm1Dli/Crebbp+   involves: 129S6/SvEvTac * C57BL/6 J:60630
Ctsgtm2.1(PML/RARA)Ley/Ctsg+   involves: 129X1/SvJ * C57BL/6 J:84230, J:86458
Mll1tm1Saam/Mll1+
Tg(Mx1-cre)1Cgn/0
3 involves: 129S1/Sv * C57BL/6 * CBA J:140628
Mll1tm2(MLLT3)Thr/Mll1+   involves: 129P2/OlaHsd J:56340
Nr4a1tm1Jmi/Nr4a1tm1Jmi
Nr4a3tm1Omc/Nr4a3tm1Omc
  involves: 129S/SvEv * 129S2/SvPas * C57BL/6 J:121903
Sfpi1tm1.3Dgt/Sfpi1tm1.3Dgt   involves: 129 * BALB/c * C57BL/6 J:90331

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory