Human Disease and Mouse Model Detail

Human Disease

Term: Asthma, Susceptibility to
OMIM ID: 600807

Synonyms

Asthma, Bronchial

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Il4ra	IL4R
Itgb6	ITGB6
Runx3	RUNX3
Tbx21	TBX21

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Adrb2	ADRB2
Alox5	ALOX5
Ccl11	CCL11
H2-M3	HLA-G
Hnmt	HNMT
Il12b	IL12B
Il13	IL13
Phf11d	PHF11
Pla2g7	PLA2G7
Scgb1a1	SCGB1A1
Scgb3a2	SCGB3A2
Tnf	TNF

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Transgenes and
other mutation types

Tg(Scgb1a1-rtTA)1Jaw		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(tetO-IL1B)KBry

Mouse Models

Genotype				Ref(s)
Allelic Composition		Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Il4ra^tm1Tch/Il4ra^tm1Tch			involves: 129X1/SvJ * BALB/c	J:86215
Il4ra^tm2Tch/Il4ra^tm2Tch			C.129X1-Il4ra^tm2Tch	J:152376
Itgb6^tm1Des/Itgb6^tm1Des			involves: 129S4/SvJae * C57BL/6J	J:33139
Runx3^tm1Yg/Runx3^tm1Yg			either: (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)	J:100348
Tbx21^tm1Glm/Tbx21⁺			involves: 129S6/SvEvTac * C57BL/6	J:73832
Tbx21^tm1Glm/Tbx21^tm1Glm			involves: 129S6/SvEvTac * C57BL/6	J:73832
Models involving transgenes or other mutation types.²
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-IL1B)KBry/0			involves: 129 * C57BL/6	J:107601
No similarity to the expected human disease phenotype was found.³
NOT	Adam33^tm1.1Chch/Adam33^tm1.1Chch		129S4/SvJae-Adam33^tm1.1Chch	J:112306

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²Models involving transgenes or other mutation types may also appear in other sections of the table.
³One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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