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Human Disease and Mouse Model Detail
Human Disease

Term: Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2
OMIM ID: 600116

Synonyms Parkinson Disease, Juvenile, Autosomal Recessive; PDJ; Parkinsonism, Early-Onset, with Diurnal Fluctuation; EPDF
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Park2 PARK2
  mousehuman...both mouse and human orthologous genes.
     
Transgenes and
other mutation types
Tg(PDGFB-GPR37)20Ryot   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Prp-GPR37)1Ryot
Tg(Slc6a3-PARK2*Q311X)AXwy

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Park2tm1Ccs/Park2tm1Ccs   involves: 129S1/Sv * 129X1/SvJ * C57BL/6J J:168847
Park2tm1Roo/Park2tm1Roo   involves: 129S2/SvPas J:125148
Park2tm1Roo/Park2tm1Roo   either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) J:85561
Park2tm1Shn/Park2tm1Shn   involves: 129S4/SvJae J:86377
Park2tm1Tmd/Park2tm1Tmd   involves: C57BL/6 J:91487
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
  involves: 129P2/OlaHsd * C3H * C57BL/6 J:140326
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
  involves: 129P2/OlaHsd * C57BL/6 J:140326
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/0
  involves: 129P2/OlaHsd * C3H * C57BL/6 J:140326
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
  involves: 129P2/OlaHsd * C57BL/6 J:140326
Models involving transgenes or other mutation types.2
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
  involves: 129P2/OlaHsd * C3H * C57BL/6 J:140326
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
  involves: 129P2/OlaHsd * C57BL/6 J:140326
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/0
  involves: 129P2/OlaHsd * C3H * C57BL/6 J:140326
Park2tm1Ykt/Park2tm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
  involves: 129P2/OlaHsd * C57BL/6 J:140326
Tg(Slc6a3-PARK2*Q311X)AXwy/0   FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy J:146833

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory