Human Disease and Mouse Model Detail

Human Disease

Term: Myelocytic Leukemia-Like Syndrome, Familial, Chronic
OMIM ID: 600080

Synonyms

CML-Like Syndrome, Familial

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Flt3	FLT3
Irf8	IRF8
Slc11a1	SLC11A1

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.¹
Flt3^tm1Dgg/Flt3^tm1Dgg		involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:126003
Flt3^tm1Dgg/Flt3⁺		involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:126003
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r		BXH2/TyJ-Irf8^myls	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r		involves: A/J * BXH2/TyJ	J:97931
Irf8^tm1Hor/Irf8^tm1Hor		either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	J:36038
Irf8^tm1Hor/Irf8⁺		either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	J:36038

¹The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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