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Human Disease and Mouse Model Detail
Human Disease

Term: Heterotaxy, Visceral, 1, X-Linked; HTX1
OMIM ID: 306955

Synonyms Dextrocardia with Other Cardiac Malformations; Laterality, X-Linked
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Zic3 ZIC3
  mousehuman...both mouse and human orthologous genes.
     

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Zic3Bn/Zic3Bn   BNT/LeJ 5
Zic3Bn/Zic3+   BNT/LeJ 5
Zic3tm1Bca/Y   involves: 129S7/SvEvBrd J:75951
Zic3tm1Bca/Zic3+   involves: 129S7/SvEvBrd * C57BL/6 J:75951
Zic3tm1Bca/Y   involves: 129S7/SvEvBrd * C57BL/6 J:75951
Zic3tm1Bca/Zic3tm1Bca   involves: 129S7/SvEvBrd * C57BL/6 J:75951

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory