Human Disease and Mouse Model Detail

Human Disease

Term: Werner Syndrome; WRN
OMIM ID: 277700

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Wrn

WRN

...both mouse and human orthologous genes.

Terc

TERC

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Transgenes and
other mutation types

Tg(CAG-WRN*K577M)5025Wcl

Characteristics of this human disease are associated with transgenes and other mutation types in mouse.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Terc^tm1Rdp/Terc^tm1Rdp Wrn^tm1Lgu/Wrn^tm1Lgu		involves: 129/Sv * BALB/c * C57BL/6 * SLJ	J:91715
Wrn^tm1Led/Wrn^tm1Led		B6.129S6(BKSW)-Wrn^tm1Led	J:106446
Models involving transgenes or other mutation types.²
Tg(CAG-WRN*K577M)5025Wcl/0		involves: C3H * C57BL/6J	J:95127

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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