Human Disease and Mouse Model Detail

Human Disease

Term: Sjogren Syndrome
OMIM ID: 270150

Synonyms

Sicca Syndrome

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Aire	AIRE
Ccr7	CCR7
E2f1	E2F1
Fas	FAS
Id3	ID3
Il1r1	IL1R1
Il4	IL4
Map3k14	MAP3K14
Nfkbia	NFKBIA
plt	none identified
sld	none identified
Tgfb1	TGFB1
Thbs1	THBS1
Tnfrsf9	TNFRSF9
Traf3ip2	TRAF3IP2

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Transgenes and
other mutation types

Tg(Psp-Rbbp4)1Yoha		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Tnfsf13b)1Fma

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background	Ref(s)
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.¹
Aire^tm1.1Doi/Aire^tm1.1Doi Il1r1^tm1Imx/Il1r1⁺		involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	J:163691
Aire^tm1.1Doi/Aire^tm1.1Doi Il1r1^tm1Imx/Il1r1^tm1Imx		involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	J:163691
Aire^tm1Mmat/Aire^tm1Mmat		involves: C57BL/6 * CBA	J:96580
Ccr7^tm1Rfor/Ccr7^tm1Rfor		B6.129P2-Ccr7^tm1Rfor	J:110910
E2f1^tm1Meg/E2f1^tm1Meg		NOD.Cg-E2f1^tm1Meg	J:93708
Fas^lpr/Fas^lpr		MRL/MpJ-Fas^lpr/J	J:123192
Fas^lpr/Fas^lpr Tnfrsf9^tm1Byk/Tnfrsf9^tm1Byk		MRL.Cg-Tnfrsf9^tm1Byk Fas^lpr	J:120559
Fas^lpr/Fas^lpr		MRL/Mp-Fas^lpr	J:1028, J:18512, J:21965
Fas^lpr/Fas^lpr		C3.MRL-Fas^lpr	J:1028
Id3^tm1Zhu/Id3^tm1Zhu		involves: 129S4/SvJaeSor	J:93916
Id3^tm2.1Zhu/Id3^tm2.1Zhu Tg(Lck-cre)#Zhu/0	3	involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J	J:172701
Il4^tm1Cgn/Il4^tm1Cgn		NOD.Cg-H2^b Il4^tm1Cgn	J:105803
Il4^tm1Cgn/Il4^tm1Cgn		NOD.129P2-Il4^tm1Cgn	J:105803
Map3k14^aly/Map3k14^aly		involves: C57BL/6J	J:38580
Nfkbia^tm1.1Pjc/Nfkbia^tm1.1Pjc		involves: C57BL/6	J:163686
plt/plt		either: B6.DDD-plt or C.DDD-plt	J:110910
sld/sld		NFS/N-sld	J:20364, J:62145, J:106272
Tgfb1^tm1Doe/Tgfb1^tm1Doe		involves: 129S2/SvPas * CF1	J:2892
Thbs1^tm1Hyn/Thbs1^tm1Hyn		involves: 129S2/SvPas * C57BL/6	J:153126
Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix		C.129-Traf3ip2^tm1.1Lix	J:138560
Models involving transgenes or other mutation types.²
Tg(Psp-Rbbp4)1Yoha/0		involves: C57BL/6	J:141378
Tg(Tnfsf13b)1Fma/0		B6.Cg-Tg(Tnfsf13b)1Fma	J:73711

¹The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
²Models involving transgenes or other mutation types may also appear in other sections of the table.
³Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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