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Human Disease and Mouse Model Detail
Human Disease

Term: Pancreatic Cancer
OMIM ID: 260350

Synonyms Pancreatic Acinar Carcinoma; Pancreatic Carcinoma
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Kras KRAS
Trp53 TP53
  mousehuman...both mouse and human orthologous genes.
     
Bcl2l1 BCL2L1
Brca2 BRCA2
Cdkn2a CDKN2A
Pten PTEN
Ptf1a PTF1A
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Transgenes and
other mutation types
Tg(Ela1-Myc)158Bri   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Ela1-Myc)159Bri
Tg(Ela1-Myc)160Bri
Tg(Ela1-TAg)18Bri
Tg(Ela1-TAg)19Bri
Tg(Ins2-Tag*,-flpe)#Gne
Tg(RIP1-Tag)2Dh
Tg(RIR-Tag)87Dh

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Brca2tm1Brn/Brca2tm1Cam
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Ipf1-cre)6Tuv/0
4 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N J:166678
Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53+
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129 * C57BL/6 * CBA * FVB/N J:108298
Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129 * C57BL/6 * CBA * FVB/N J:108298
Cdkn2atm2.1Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129 * C57BL/6 * CBA * FVB/N J:108298
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129S4/SvJae * C57BL/6 * CBA J:187012
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N J:87196, J:108298
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129 * C57BL/6 * CBA * FVB/N J:108298
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Ipf1-cre)6Tuv/0
4 involves: 129S4/SvJae * C57BL/6 * FVB/N J:98936
Krastm4Tyj/Kras+
Ptentm1Hwu/Pten+
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129S4/SvJae * BALB/c * C57BL/6 J:164210
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre)89.1Dam/0
4 involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA J:164210
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
4 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ J:87973
Krastm4Tyj/Kras+
Tg(Ipf1-cre)6Tuv/?
4 involves: 129S4/SvJae * FVB/N J:87973
Models with phenotypic similarity to human disease where etiologies are distinct.2
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(Ins2-cre)25Mgn/0
Tg(RIP1-Tag)2Dh/0
  involves: 129S6/SvEvTac * C57BL/6 * DBA J:146436
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(RIP1-Tag)2Dh/0
  involves: 129S6/SvEvTac * C57BL/6 * DBA J:146436
Models involving transgenes or other mutation types.3
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(Ins2-cre)25Mgn/0
Tg(RIP1-Tag)2Dh/0
  involves: 129S6/SvEvTac * C57BL/6 * DBA J:146436
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(RIP1-Tag)2Dh/0
  involves: 129S6/SvEvTac * C57BL/6 * DBA J:146436
Tg(Ela1-Myc)158Bri/0   involves: C57BL/6 * SJL J:76992
Tg(Ela1-Myc)159Bri/0   involves: C57BL/6 * SJL J:76992
Tg(Ela1-Myc)160Bri/0   involves: C57BL/6 * SJL J:76992
Tg(Ela1-TAg)18Bri/0   involves: C57BL/6 * SJL J:76995
Tg(Ela1-TAg)19Bri/0   involves: C57BL/6 * SJL J:76995
Tg(Ins2-Tag*,-flpe)#Gne/0 4 Not Specified J:188693
Tg(Ins2-Tag*,-flpe)#Gne/0 4 involves: C57BL/6J J:187012
Tg(RIP1-Tag)2Dh/0   involves: C57BL/6J * DBA/2J J:50695
Tg(RIR-Tag)87Dh/0   involves: C57BL/6J * DBA/2J J:50695

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory