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Human Disease and Mouse Model Detail
Human Disease

Term: Neuroblastoma, Susceptibility to
OMIM ID: 256700

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Nf1 NF1
Rb1 RB1
Trp53 TP53
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Kif1b KIF1B
Nme1 NME1
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(OMP-SV40T)13Bse   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(rTH-Tag)20Dmc
Tg(tetO-TAg)2-5Hiwa
Tg(Th-MYCN)41Waw

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Nf1tm1Tyj/Nf1+
Tg(Th-MYCN)41Waw/0
  involves: 129S2/SvPas * BALB/c * C57BL/6J J:41126
Rb1tm1Tyj/Rb1+
Tg(Th-MYCN)41Waw/0
  involves: 129S2/SvPas * BALB/c * C57BL/6J J:41106
Tg(Th-MYCN)41Waw/0
Trp53tm1Brd/Trp53+
  involves: 129S7/SvEvBrd * BALB/c * C57BL/6J * FVB/N J:41126
Models involving transgenes or other mutation types.2
Nf1tm1Tyj/Nf1+
Tg(Th-MYCN)41Waw/0
  involves: 129S2/SvPas * BALB/c * C57BL/6J J:41126
Rb1tm1Tyj/Rb1+
Tg(Th-MYCN)41Waw/0
  involves: 129S2/SvPas * BALB/c * C57BL/6J J:41106
Tg(OMP-SV40T)13Bse/0   involves: C57BL/6 * SJL J:54269
Tg(rTH-Tag)20Dmc/0   involves: C57BL/6NTac * DBA/2NTac J:90323
Tg(tetO-TAg)2-5Hiwa/0   involves: C57BL/6 J:156984, J:175962
Tg(Th-MYCN)41Waw/0   involves: BALB/c * C57BL/6J J:41126
Tg(Th-MYCN)41Waw/Tg(Th-MYCN)41Waw   involves: BALB/c * C57BL/6J J:41126
Tg(Th-MYCN)41Waw/0   involves: BALB/c * C57BL/6J * FVB/N J:141126
Tg(Th-MYCN)41Waw/0
Trp53tm1Brd/Trp53+
  involves: 129S7/SvEvBrd * BALB/c * C57BL/6J * FVB/N J:41126
Tg(Th-MYCN)41Waw/0   involves: 129X1/SvJ * BALB/c * C57BL/6J J:172448

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory