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Human Disease and Mouse Model Detail
Human Disease

Term: Mucopolysaccharidosis Type VI
OMIM ID: 253200

Synonyms Arsb Deficiency; Arylsulfatase B Deficiency; Maroteaux-Lamy Syndrome; MPS VI; MPS6; N-Acetylgalactosamine-4-Sulfatase Deficiency
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Arsb ARSB
  mousehuman...both mouse and human orthologous genes.
     

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Arsbm1J/Arsbm1J   C57BL/6J-Arsbm1J/GrsrJ J:149960
Arsbtm1Cptr/Arsbtm1Cptr   involves: 129P2/OlaHsd * C57BL/6J J:34831
Arsbtm1Cptr/Arsbtm1Cptr   involves: 129P2/OlaHsd * 129S2/SvPas J:102290

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory