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Human Disease and Mouse Model Detail
Human Disease

Term: Diabetes Mellitus, Insulin-Dependent; IDDM
OMIM ID: 222100

Synonyms Diabetes Mellitus, Type I
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Ager AGER
B2m B2M
Casp1 CASP1
Cd38 CD38
Cd4 CD4
Cd80 CD80
Cd86 CD86
Cdk4 CDK4
E2f1 E2F1
Fas FAS
Foxo1 FOXO1
Gad2 GAD2
H2-Ab1 HLA-DQB1
Ifng IFNG
Ifngr2 IFNGR2
Ighm IGHM
Il1r1 IL1R1
Il4 IL4
Ins1 none identified
Ins2 INS
Pdpk1 PDPK1
Pdx1 PDX1
Prf1 PRF1
Prkdc PRKDC
Ptprn2 PTPRN2
Rag1 RAG1
Sell SELL
Stat4 STAT4
Tnfsf4 TNFSF4
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Foxp3 FOXP3
Hnf1a HNF1A
Il6 IL6
Itpr3 ITPR3
Oas1g OAS1
Ptpn22 PTPN22
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
H2   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Cryaa-TAg)1Ove
Tg(H2-Ea)12Lt
Tg(H2-Ea-G6pc2)69Tkay
Tg(H2-Ea-Ins2)1Wehi
Tg(HLA-A/H2-D/B2M)1Dvs
Tg(HLA-DQA1,HLA-DQB1)1Dv
Tg(HLA-DRB1)31Dmz
Tg(Igh-6/Igh-V125)2Jwt
Tg(Igh-6/Igh-V281)3Jwt
Tg(IghelMD4)4Ccg
Tg(Igh-VB1-8/Igh-6m)1Mjsk
Tg(Igk-C/Igk-V125)1Jwt
Tg(Ins1-Cat,Tyr)25Pne
Tg(Ins2-CALM1)26Ove
Tg(Ins2-CD80)3B7Flv
Tg(Ins2-CD86)12B70Flv
Tg(Ins2-Fas*I246N)1Ach
Tg(Ins2-Fasl)24Ach
Tg(Ins2-GP)34-20Olds
Tg(Ins2-HA)165Bri
Tg(Ins2-Nos2)31Okam
Tg(Ins2-Nos2)40Okam
Tg(Ins2-NP)25-3Olds
Tg(Ins2*Y16A)1Ell
Tg(Ins2*Y16A)3Ell
Tg(INS-Il10)#Sar
Tg(INS-MT2A,Tyr)1Pne
Tg(INS-SOD2)3Pne
Tg(Kdr-AGER)102Hyam
Tg(TcraAI4)1Dvs
Tg(TcraBDC12-4.1)10Jos
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Tg(Tcra/Tcrb)1Vbo
Tg(TcraTcrbNY8.3)1Pesa
Tg(TcrbAI4)1Dvs
Tg(TcrbBDC12-4.1)82Gse

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Agertm1.1Hyam/Agertm1.1Hyam   involves: 129P2/OlaHsd * C57BL/6J * CD-1 J:116507
Agertm1.1Hyam/Agertm1.1Hyam
Tg(Ins2-Nos2)40Okam/0		   involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 J:116040
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0		   NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs J:121685
Casp1tm1Sesh/Casp1tm1Sesh   NOD.129S2(B6)-Casp1tm1Sesh/LtJ J:87250
Cd38tm1Lnd/Cd38tm1Lnd   NOD.129P2(B6)-Cd38tm1Lnd/LtJ J:108097
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr		   involves: 129S4/SvJae * NOD J:61905
Cdk4tm1Bbd/Cdk4tm1Bbd   involves: 129S1/Sv * 129X1/SvJ * ICR J:54534
E2f1tm1Meg/E2f1tm1Meg   NOD.Cg-E2f1tm1Meg J:93708
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0		   NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach J:81416
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0		 4 Not Specified J:85985
Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0		 4 involves: 129S4/SvJae * C57BL/6J * CBA/J J:109224
Gad2tm1Miya/Gad2tm1Miya   NOD.129P2-Gad2tm1Miya J:88785
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0		   involves: 129S2/SvPas * C57BL/6 * CBA * SJL J:68641
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0		   involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL J:68641
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0		   B6.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv J:59245
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
Ifngtm1Ts/Ifngtm1Ts   NOD.129S7(B6)-Ifngtm1Ts Prkdcscid J:72818
Ifngtm1Ts/Ifngtm1Ts   NOD.129S7(B6)-Ifngtm1Ts/DvsJ J:72818
Ifngr2tm1Pbro/Ifngr2tm1Pbro   NOD.129S1-Ifngr2tm1Pbro J:72818
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0		   NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt J:91865
Ighmtm1Cgn/Ighm+   NOD.129S2-Ighmtm1Cgn J:37287
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-VB1-8/Igh-6m)1Mjsk/?		   NODCaj.Cg-Ighmtm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ J:93190
Il1r1tm1Roml/Il1r1tm1Roml   NOD.Cg-Il1r1tm1Roml J:87251
Il4tm1Cgn/Il4tm1Cgn   either: NOD.129-Il4tm1Cgn or (involves: 129 * NOD) J:85924
Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0		   NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi J:85924
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0		   NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell J:98583
Ins2tm1Jja/Ins2tm1Jja   NOD.129S2-Ins2tm1Jja J:85309
Pdx1tm1Cvw/Pdx1tm4Cvw
Tg(Ins2-cre)25Mgn/0		 4 involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA J:130389
Prf1tm1Clrk/Prf1tm1Clrk   involves: 129S7/SvEvBrd * BALB/c * NOD J:64051
Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0		   involves: 129S7/SvEvBrd * BALB/c * NOD J:64051
Prf1tm1Sdz/Prf1tm1Sdz   NOD.B6-Prf1tm1Sdz J:43468
Prf1tm1Sdz/Prf1+   NOD.B6-Prf1tm1Sdz J:43468
Prkdcscid/Prkdcscid
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD.Cg-Prkdcscid Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553
Ptprn2tm1Aln/Ptprn2tm1Aln   involves: 129S4/SvJae * C57BL/6N * NOD/LtJ J:81889
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:94192
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
Selltm1Flv/Selltm1Flv   involves: C57BL/6 * NOD J:88974
Selltm1Flv/Sell+   NOD.Cg-Selltm1Flv J:88974
Selltm1Flv/Sell+   involves: C57BL/6 * NOD J:88974
Selltm1Flv/Selltm1Flv   NOD.Cg-Selltm1Flv J:88974
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-GP)34-20Olds/0		   involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-NP)25-3Olds/0		   involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047
Stat4tm1Gru/Stat4+   NOD.129S2-Stat4tm1Gru J:90600
Stat4tm1Gru/Stat4tm1Gru   C.129S2-Stat4tm1Gru J:106340
Tnfsf4tm1Shr/Tnfsf4tm1Shr   NOD.129S4-Tnfsf4tm1Shr J:86926
Models involving transgenes or other mutation types.2
Agertm1.1Hyam/Agertm1.1Hyam
Tg(Ins2-Nos2)40Okam/0		   involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 J:116040
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0		   NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs J:121685
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0		   NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach J:81416
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0		 4 Not Specified J:85985
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0		   involves: 129S2/SvPas * C57BL/6 * CBA * SJL J:68641
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0		   involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL J:68641
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0		   B6.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv J:59245
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0		   NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt J:91865
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-VB1-8/Igh-6m)1Mjsk/?		   NODCaj.Cg-Ighmtm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ J:93190
Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0		   NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi J:85924
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0		   NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell J:98583
Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0		   involves: 129S7/SvEvBrd * BALB/c * NOD J:64051
Prkdcscid/Prkdcscid
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD.Cg-Prkdcscid Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:94192
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		   involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-GP)34-20Olds/0		   involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-NP)25-3Olds/0		   involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047
Tg(Cryaa-TAg)1Ove/0
Tg(Ins2-CALM1)26Ove/0		   FVB/N J:97926
Tg(H2-Ea-G6pc2)69Tkay/?   NOD-Tg(H2-Ea-G6pc2)69Tkay J:117352
Tg(H2-Ea-Ins2)1Wehi/0   NOD/LtJWehi-Tg(H2-Ea-Ins2)1Wehi J:100251
Tg(H2-Ead)12Lt/0   NOD/ShiLt-Tg(H2-Ead)12Lt J:36435
Tg(HLA-A/H2-D/B2M)1Dvs/0   NOD/ShiLtDvs-Tg(HLA-A/H2-D/B2M)1Dvs J:121685
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0		   NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt J:91865
Tg(Igh-6/Igh-V281)3Jwt/0   NOD.B6-Tg(Igh-6/Igh-V281)3Jwt J:91865
Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg   NOD.B6-Tg(IghelMD4)4Ccg/DvsJ J:80859
Tg(INS-MT2A,Tyr)1Pne/0   NOD.FVB-Tg(INS-MT2A,Tyr)1Pne J:108415
Tg(INS-MT2A,Tyr)1Pne/0   FVB-Tg(INS-MT2A,Tyr)1Pne J:100251
Tg(INS-SOD2)3Pne/0   NOD.FVB-Tg(INS-SOD2)3Pne J:108415
Tg(Ins1-Cat,Tyr)25Pne/0   NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne J:108415
Tg(Ins1-Cat,Tyr)25Pne/0   involves: FVB J:59725
Tg(Ins2*Y16A)3Ell/0   NOD-Tg(Ins2*Y16A)3Ell J:98583
Tg(Ins2-CD80)3B7Flv/?   involves: C57BL/6 * CBA/Ca * NOD/Caj J:26618
Tg(Ins2-CD86)12B70Flv/0   involves: C57BL/6 * CBA/Ca J:93555
Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0		   NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach J:81416
Tg(Ins2-Fasl)24Ach/0   NOD-Tg(Ins2-Fasl)24Ach J:78679
Tg(Ins2-GP)34-20Olds/0   involves: BALB/c * C57BL/6 J:81287
Tg(Ins2-Nos2)31Okam/0   involves: C57BL/6 * CD-1 * DBA/2 J:45520
Tg(Ins2-Nos2)40Okam/0
Tg(Kdr-AGER)102Hyam/0		   involves: C57BL/6J * CBA/J * CD-1 * DBA/2 J:70495
Tg(Ins2-Nos2)40Okam/0   involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 J:116040
Tg(Ins2-Nos2)40Okam/0   involves: C57BL/6 * CD-1 * DBA/2 J:4552
Tg(Ins2-NP)25-3Olds/0   involves: BALB/c * C57BL/6 J:81284
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD-Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553
Tg(TcraAI4)1Dvs/0   NOD-Tg(TcraAI4)1Dvs J:93553
Tg(TcraTcrbNY8.3)1Pesa/?   involves: C57BL/6 * NOD * SJL J:44202
No similarity to the expected human disease phenotype was found.3
NOT B2mtm1Jae/B2mtm1Jae
Tg(B2m)1Rms/0
Tg(INS-cre)2Rms/0		 4 involves: 129S2/SvPas * NOD J:83635
NOT B2mtm1Unc/B2mtm1Unc   NOD.129P2-B2mtm1Unc J:17000
NOT B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		   NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553
NOT B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum		   NOD.Cg-B2mtm1Unc Ciitatm1Ccum J:107051
NOT Casp3tm1Mak/Casp3tm1Mak   B6.129P2-Casp3tm1Mak J:97650
NOT Cd4tm1Knw/Cd4tm1Knw   NOD.Cg-Cd4tm1Knw J:93553
NOT Ciitatm1Ccum/Ciitatm1Ccum   NOD.129S2(B6)-Ciitatm1Ccum J:106081
NOT Ctnna2tm1Mta/Ctnna2tm1Mta   Not Specified J:83635
NOT Faslpr/Faslpr   NOD.MRL(B6)-Faslpr J:64051
NOT H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell		   NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell J:87013
NOT Icam1tm1Jcgr/Icam1tm1Jcgr
Tg(INS-Il10)#Sar/0		   NOD.Cg-Icam1tm1Jcgr Tg(INS-Il10)#Sar J:98583
NOT Ighmtm1Cgn/Ighmtm1Cgn
Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg		   NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ J:80859
NOT Ighmtm1Cgn/Ighmtm1Cgn   NOD.129S2-Ighmtm1Cgn/DvsJ J:80859
NOT Ighmtm1Cgn/Ighmtm1Cgn   NOD.129S2-Ighmtm1Cgn J:37287
NOT Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0		   NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell J:98583
NOT Ins1tm1Jja/Ins1tm1Jja   NOD.129S2-Ins1tm1Jja J:85309
NOT Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0		   NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)3Ell J:98583
NOT Parp1tm1Hsmm/Parp1tm1Hsmm   involves: 129S4/SvJae J:53360
NOT Stat4tm1Gru/Stat4tm1Gru   NOD.129S2-Stat4tm1Gru J:90600
NOT Tg(H2-Ead)5Lt/0   NOD/ShiLt-Tg(H2-Ead)5Lt J:36435
NOT Tg(TcrbAI4)1Dvs/0   NOD-Tg(TcrbAI4)1Dvs J:93553
NOT Tlr2tm1Aki/Tlr2tm1Aki   NOD.129P2-Tlr2tm1Aki J:124334

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.
3One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.
4Conditionally targeted allele(s)
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory