Human Disease and Mouse Model Detail

Human Disease

Term: Cryptorchidism, Unilateral or Bilateral
OMIM ID: 219050

Synonyms

Undescended Testis

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Insl3

INSL3

...both mouse and human orthologous genes.

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

RXFP2

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Ar^Tfm/Y Insl3^tm1Imad/Insl3^tm1Imad		involves: 129/Sv * CD-1 * STOCK Eda^Ta	J:83429
Insl3^tm1Imad/Insl3^tm1Imad		involves: 129/Sv * CD-1	J:83429
Insl3^tm1Imad/Insl3^tm1Imad		involves: 129/Sv	J:83429
Insl3^tm1Par/Insl3^tm1Par		involves: 129/Sv * CD-1	J:55881
Insl3^tm1Par/Insl3⁺		involves: 129/Sv * CD-1	J:55881

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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