Human Disease and Mouse Model Detail

Human Disease

Term: Fraser Syndrome
OMIM ID: 219000

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Fras1	FRAS1
Frem2	FREM2

...both mouse and human orthologous genes.

Frem1	FREM1
Grip1	GRIP1

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Fras1^bl/Fras1^bl		involves: 101/H * C3H/HeH	J:83745
Fras1^bl/Fras1^bl Frem2^my-Ucl/Frem2^my-Ucl		involves: 101/H * C3H/HeH * NMRI	J:98344
Fras1^tm1Chpk/Fras1^tm1Chpk		involves: 129S1/Sv * 129X1/SvJ * C57BL/10	J:83746
Fras1^tm1Chpk/Fras1^tm1Chpk		involves: 129S1/Sv * 129X1/SvJ * NMRI	J:137010
Frem2^{Gt(KST252)Byg}/Frem2^my-Ucl		involves: 129P2/OlaHsd * CD-1 * NMRI	J:98344
Frem2^my-Ucl/Frem2^my-Ucl		involves: NMRI	J:98344
Frem2^my/Frem2^my		MY/HuLeJ	J:111788
Frem2^ne/Frem2^ne		STOCK Frem2^ne/GrsrJ	J:185265
Models with phenotypic similarity to human disease where etiologies are distinct.²
Frem1^bat/Frem1^bat		C57BL/6J-Frem1^bat	J:92613
Frem1^bfd/Frem1^bfd		involves: C57BL/6J	J:92613
Frem1^heb/Frem1^heb		AKR/J	J:92613
Frem1^tm1Ksek/Frem1^tm1Ksek		involves: 129 * C57BL/6	J:111788
Grip1^eb/Grip1^eb		involves: ATEB/Le * C57BL/6J	J:111788
Grip1^tm1Rha/Grip1^tm1Rha		B6.129-Grip1^tm1Rha	J:88266

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/03/2013 MGI 5.12