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Human Disease and Mouse Model Detail
Human Disease

Term: Apparent Mineralocorticoid Excess; AME
OMIM ID: 218030

Synonyms Ame1; Cortisol 11-Beta-Ketoreductase Deficiency
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Hsd11b2 HSD11B2
  mousehuman...both mouse and human orthologous genes.
     

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Hsd11b2tm1Yko/Hsd11b2tm1Yko   involves: 129P2/OlaHsd * MF1 J:53391

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory