Human Disease and Mouse Model Detail

Human Disease

Term: Chediak-Higashi Syndrome; CHS
OMIM ID: 214500

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Lyst

LYST

...both mouse and human orthologous genes.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Lyst^bg-14J/Lyst^bg-14J		C3Fe;B6-Lyst^bg-14J	J:85200
Lyst^bg-2Btlr/Lyst^bg-2Btlr		C57BL/6J-Lyst^bg-2Btlr	J:133617
Lyst^bg-Btlr/Lyst^bg-Btlr		C57BL/6J-Lyst^bg-Btlr	J:133616
Lyst^bg-grey/Lyst^bg-grey		C57BL/6-Lyst^bg-grey	J:106442
Lyst^bg-Lac/Lyst^bg-Lac		CBA/CaLac-Lyst^bg-Lac	J:29745
Lyst^bg-slt/Lyst^bg-slt		YZ57/Ch	J:25388
Lyst^bg/Lyst^bg		B6.C3Rl-Lyst^bg/J	J:6801
Lyst^bg/Lyst^bg		B6.C3Rl-Lyst^bg	8

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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