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Human Disease and Mouse Model Detail
Human Disease

Term: Lung Cancer
OMIM ID: 211980

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Kras KRAS
  mousehuman...both mouse and human orthologous genes.
     
Ctnnb1 CTNNB1
Fgfr3 FGFR3
Foxm1 FOXM1
Gadd45a GADD45A
Robo1 ROBO1
Tgfbr2 TGFBR2
Trp53 TP53
Xpc XPC
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Braf BRAF
Casp8 CASP8
Dlec1 DLEC1
Egfr EGFR
Erbb2 ERBB2
Ercc6 ERCC6
Fasl FASLG
Irf1 IRF1
Map3k8 MAP3K8
Park2 PARK2
Pik3ca PIK3CA
Ppp2r1b PPP2R1B
Rassf1 RASSF1
Slc22a18 SLC22A18
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Scgb1a1-rtTA)1Jaw   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(SFTPC-EML4/ALK)502-4Hima
Tg(SFTPC-env)1Yhch
Tg(tetO-PIK3CA*H1047R)13Lca

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Krastm2Tyj/Kras+
Trp53tm1Glo/Trp53+
  involves: 129S2/SvPas * 129S7/SvEvBrd J:129627
Krastm2Tyj/Kras+   involves: 129S2/SvPas * C57BL/6 J:68981
Krastm2Tyj/Kras+   involves: 129S2/SvPas J:68981, J:136369
Krastm3Tyj/Kras+   involves: 129S2/SvPas * C57BL/6 J:68981
Krastm3Tyj/Kras+   involves: 129S2/SvPas J:68981
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
4 B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm J:177379
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
4 involves: 129P2/OlaHsd * 129S4/SvJae J:103407, J:154041
Krastm4Tyj/Kras+
Trp53tm1.1Dgk/Trp53tm1.1Dgk
4 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ J:187012
Models with phenotypic similarity to human disease where etiologies are distinct.2
Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0
4 involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N J:174242
Foxm1tm1Rhc/Foxm1tm1Rhc
Tg(Tek-cre)1Ywa/0
4 involves: 129X1/SvJ * C57BL/6 * SJL J:167773
Gadd45atm1Ajf/Gadd45atm1Ajf
Xpctm1Ecf/Xpctm1Ecf
  either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6) J:101421
Robo1tm1Phr/Robo1+   involves: 129P2/OlaHsd * C57BL/6 J:93666
Xpctm1Ecf/Xpctm1Ecf   involves: 129 * C57BL/6 J:101421
Models involving transgenes or other mutation types.3
Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-PIK3CA*H1047R)13Lca/0
  involves: 129 * C57BL/6 * FVB/N J:142254
Tg(SFTPC-EML4/ALK)502-4Hima/0   involves: C57BL/6J J:142679
Tg(SFTPC-env)1Yhch/0   FVB/N-Tg(SFTPC-env)1Yhch J:153538

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory