Human Disease and Mouse Model Detail

Human Disease

Term: Wolff-Parkinson-White Syndrome
OMIM ID: 194200

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Bmpr1a

BMPR1A

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Prkag2	PRKAG2
Tbx1	TBX1

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Transgenes and
other mutation types

Tg(CAG-Map3k7*K63W)1232Mds		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Myh6-PRKAG2*R302Q)#Rro
Tg(Myh6-PRKAG2*R531G)22Dca

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(GATA6-cre)#Jbeb/0	3	involves: 129S7/SvEvBrd * C57BL/6 * FVB	J:111392
Models involving transgenes or other mutation types.²
Tg(CAG-Map3k7*K63W)1232Mds/0 Tg(Myh6-cre)2182Mds/0	3	involves: FVB/N	J:117108
Tg(Myh6-PRKAG2*R302Q)#Rro/0		involves: FVB	J:108102
Tg(Myh6-PRKAG2*R531G)22Dca/0		involves: C57BL/10 * CBA/Ca	J:108517

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²Models involving transgenes or other mutation types may also appear in other sections of the table.
³Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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