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Human Disease and Mouse Model Detail
Human Disease

Term: Denys-Drash Syndrome; DDS
OMIM ID: 194080

Synonyms Drash Syndrome; Nephropathy, Wilms Tumor, and Genital Anomalies; Wilms Tumor and Pseudo- or True Hermaphroditism
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Wt1 WT1
  mousehuman...both mouse and human orthologous genes.
     

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Wt1tm1.1Lahe/Wt1+   involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL J:154995
Wt1tm1Mlh/Wt1+   involves: 129P2/OlaHsd * C57BL/6 * MF1 J:135449
Wt1tm1Mlh/Wt1+   129P2/OlaHsd-Wt1tm1Mlh J:135449
Wt1tm1Mlh/Wt1+   involves: 129P2/OlaHsd * C57BL/6 J:135449
Wt1tm1Vih/Wt1+   involves: 129S7/SvEvBrd * C57BL/6 * MF1 J:94225
Wt1tm2Hst/Wt1+   chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac J:53585, J:103489

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory