Human Disease and Mouse Model Detail

Human Disease

Term: White Sponge Nevus; WSN
OMIM ID: 193900

Synonyms

Leukokeratosis, Hereditary Mucosal; White Sponge Nevus of Cannon

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Krt4

KRT4

...both mouse and human orthologous genes.

Krt13

KRT13

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Krt4^Bcc1/Krt4^Bcc1		C3HeB/FeJ-Krt4^Bcc1	J:116740
Krt4^Bcc1/Krt4⁺		C3HeB/FeJ-Krt4^Bcc1	J:116740

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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