Human Disease and Mouse Model Detail

Human Disease

Term: Preeclampsia/Eclampsia 1; PEE1
OMIM ID: 189800

Synonyms

PEE; PREG1

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Cdkn1c	CDKN1C
Comt	COMT
Notch2	NOTCH2
Ptgs1	PTGS1

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Ephx1	EPHX1
Nos3	NOS3

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Cdkn1c^tm1Kat/Cdkn1c^tm1Kat		involves: 129P2/OlaHsd	J:102331
Cdkn1c^tm1Kat/Cdkn1c⁺		involves: 129P2/OlaHsd	J:102331
Comt^tm1Kara/Comt^tm1Kara		involves: 129S4/SvJaeSor	J:137276
Notch2^tm3Grid/Notch2^tm3Grid Tg(Tpbpa-cre,-EGFP)5Jcc/0	2	involves: 129S1/Sv	J:173527
Ptgs1^tm1Fun/Ptgs1^tm1Fun		involves: 129S6/SvEvTac * C57BL/6	J:97351

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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