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Human Disease and Mouse Model Detail
Human Disease

Term: Thyroid Hormone Resistance, Generalized, Autosomal Dominant; GRTH
OMIM ID: 188570

Synonyms Gthr; Hyperthyroxinemia, Familial Euthyroid, Secondary to Pituitary and Peripheral Resistance to Thyroid Hormones; Thyroid Hormone Unresponsiveness
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Thrb THRB
  mousehuman...both mouse and human orthologous genes.
     

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Thrbtm1.1Syc/Thrb+   involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss J:65885
Thrbtm1.1Syc/Thrbtm1.1Syc   involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss J:65885
Thrbtm1.1Syc/Thrbtm1.1Syc   involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss J:124153
Thrbtm2Few/Thrb+   involves: 129X1/SvJ * C57BL/6 J:77623
Thrbtm2Few/Thrbtm2Few   involves: 129X1/SvJ * C57BL/6 J:77623

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory