Human Disease and Mouse Model Detail

Human Disease

Term: Thyroid Carcinoma, Follicular; FTC
OMIM ID: 188470

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Pten

PTEN

...both mouse and human orthologous genes.

Men1	MEN1
Thrb	THRB

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Hras1	HRAS
Minpp1	MINPP1
Nras	NRAS

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(TPO-cre)1Shk/0	3	129S1.Cg-Pten^tm2.1Ppp Tg(TPO-cre)1Shk	J:165293
Models with phenotypic similarity to human disease where etiologies are distinct.²
Men1^tm1Zqw/Men1⁺		involves: 129/Sv * 129P2/OlaHsd	J:85302
Thrb^tm1.1Syc/Thrb^tm1.1Syc		involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J	J:92629
Thrb^tm1Df/Thrb^tm1.1Syc		involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J	J:92629

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
³Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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