Human Disease and Mouse Model Detail

Human Disease

Term: Small Cell Cancer of the Lung
OMIM ID: 182280

Synonyms

SCLC1; SCLC; SCCL

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Rb1

RB1

...both mouse and human orthologous genes.

Rbl2	RBL2
Trp53	TP53

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1.1Dgk/Trp53^tm1.1Dgk	2	involves: 129 * 129S1/Sv * 129X1/SvJ	J:187012
Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn	2	involves: 129P2/OlaHsd	J:157319
Rb1^tm3Tyj/Rb1^tm3Tyj Rbl2^tm2Tyj/Rbl2^tm2Tyj Trp53^tm1Brn/Trp53^tm1Brn	2	involves: 129P2/OlaHsd * 129S4/SvJae	J:160148
Rb1^tm3Tyj/Rb1^tm3Tyj Trp53^tm1Brn/Trp53^tm1Brn	2	involves: 129P2/OlaHsd	J:160148

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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