Human Disease and Mouse Model Detail

Human Disease

Term: Rheumatoid Arthritis; RA
OMIM ID: 180300

Synonyms

Rheumatoid Arthritis, Susceptibility to

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Dnase2a	DNASE2
Ifnar1	IFNAR1
Il6st	IL6ST
Mmp14	MMP14
Ncf1	NCF1C
Tnf	TNF
Zap70	ZAP70

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Cd244	CD244
Ciita	CIITA
H2-Eb1	HLA-DRB1
Il10	IL10
Nfkbil1	NFKBIL1
Padi4	PADI4
Ptpn22	PTPN22
Slc22a4	SLC22A4

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Transgenes and
other mutation types

H2		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(CAG-SYVN1)1Tn
Tg(FCGR2A)11Mkz
Tg(HLA-DRA0101,HLA-DRB10101)1Dmz
Tg(TcraR28,TcrbR28)KRNDim

Mouse Models

Genotype				Ref(s)
Allelic Composition		Note	Genetic Background	Ref(s)
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Dnase2a^tm1Osa/Dnase2a^tm1Osa Ifnar1^tm1Agt/Ifnar1^tm1Agt			involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	J:114982
Dnase2a^tm1Osa/Dnase2a^tm2Osa Tg(Mx1-cre)1Cgn/0		4	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA	J:114982
H2^q/? Ncf1^m1J/Ncf1^m1J			B6.Cg-Ncf1^m1J H2^q	J:92437
Il6st^tm1Thir/Il6st^tm1Thir			involves: 129 * C57BL/6	J:133059
Mmp14^tm1Hbh/Mmp14^tm1Hbh			involves: 129P2/OlaHsd * Black Swiss	J:57969
Tnf^tm1Gkl/Tnf^tm2Gkl			involves: 129S/SvEv * C57BL/6	J:54056
Tnf^tm2Gkl/Tnf⁺			involves: 129S/SvEv * C57BL/6	J:54056
Tnf^tm2Gkl/Tnf^tm2Gkl			involves: 129S/SvEv * C57BL/6	J:54056
Zap70^m1Saka/Zap70^m1Saka			involves: BALB/c	J:86607
Models involving transgenes or other mutation types.²
H2^b/H2^g7 Tg(TcraR28,TcrbR28)KRNDim/0			involves: C57BL/6 * NOD * SJL	J:36815
H2^q/? Ncf1^m1J/Ncf1^m1J			B6.Cg-Ncf1^m1J H2^q	J:92437
Tg(CAG-SYVN1)1Tn/?			D1.Cg-Tg(CAG-SYVN1)1Tn	J:86009
Tg(FCGR2A)11Mkz/Tg(FCGR2A)11Mkz			involves: C57BL/6 * SJL	J:136516
Tg(HLA-DRA0101,HLA-DRB10101)1Dmz/Tg(HLA-DRA0101,HLA-DRB10101)1Dmz			involves: C57BL/6 * C57BL/10Sn * SJL/J	J:108635
Tg(TcraR28,TcrbR28)KRNDim/0			involves: C57BL/6 * NOD * SJL	J:36815
No similarity to the expected human disease phenotype was found.³
NOT	Ighm^tm1Cgn/Ighm^tm1Cgn Tg(TcraR28,TcrbR28)KRNDim/0		involves: 129S2/SvPas * C57BL/6 * NOD * SJL	J:36815

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²Models involving transgenes or other mutation types may also appear in other sections of the table.
³One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.
⁴Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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