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Human Disease and Mouse Model Detail
Human Disease

Term: Prostate Cancer
OMIM ID: 176807

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Ar AR
Brca2 BRCA2
Pten PTEN
  mousehuman...both mouse and human orthologous genes.
     
Cdkn2a CDKN2A
Ctnnb1 CTNNB1
Kras KRAS
Msmb MSMB
Nkx3-1 NKX3-1
Spry1 SPRY1
Spry2 SPRY2
Tert TERT
Trp53 TP53
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Cd82 CD82
Cdh1 CDH1
Chek2 CHEK2
Hip1 HIP1
Klf6 KLF6
Mad1l1 MAD1L1
Msr1 MSR1
Mxi1 MXI1
Zfhx3 ZFHX3
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(ARR2/Pbsn-FGF8)3Prb   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(CAG-SAC/EGFP)35Rang
Tg(Ggamma-T)15Cps
Tg(Msmb-TAg)183-2Xuan
Tg(Msmb-TAg)186-3Xuan
Tg(Pbsn-Ar*E231G)7353Ng
Tg(Pbsn-IGF1*)5305Ng
Tg(Pbsn-MYC)6Key
Tg(Pbsn-TAg)15Tvd
Tg(tetO-BRAF*V600E)29Lc
Tg(TRAMP)8247Ng
Tg(Tyr-rtTA)37Lc

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Artm1(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		   involves: 129S1/Sv * C57BL/6 J:108849
Artm1Verh/Y
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0		 4 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 J:172730
Artm2(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		   involves: 129S1/Sv * C57BL/6 J:108849
Artm3(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		   involves: 129S1/Sv * C57BL/6 J:108849
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0		 4 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 J:161511
Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+
Ptentm1Mro/Pten+
Tg(Pbsn-cre)4Prb/0		 4 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB J:184533
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0		 4 involves: 129S4/SvJae * C57BL/6 * DBA/2 J:172730
Ptentm1Hwu/Pten+
Tg(ARR2/Pbsn-FGF8)3Prb/0
Tg(Pbsn-cre)4Prb/0		 4 involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2 J:106650
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0		 4 involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2 J:93902
Ptentm1Ppp/Pten+
Tg(Pbsn-TAg)15Tvd/0		   involves: 129S1/Sv * C57BL/6 * DBA/2 J:103408
Ptentm1Rdp/Ptentm1Rdp
Terttm3Rdp/Terttm3Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0		 4 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 J:186105
Ptentm2.1Ppp/Pten+
Spry1tm1Jdli/Spry1tm1.1Jdli
Spry2tm1Mrt/Spry2tm1.1Mrt
Tg(Osr1-cre)4Mrt/0		 4 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N J:192348
Models with phenotypic similarity to human disease where etiologies are distinct.2
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(tetO-BRAF*V600E)29Lc/0
Tg(Tyr-rtTA)37Lc/0		   involves: 129/Sv * C57BL/6J * SJL J:144358
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Pbsn-cre)4Prb/0		 4 involves: 129X1/SvJ * C57BL/6 * DBA/2 J:143034
Krastm1Bbd/Kras+
Tg(Pbsn-cre)4Prb/0		 4 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 J:143034
Msmbtm1Xuan/Msmbtm1Xuan   either: (involves 129S1/Sv * 129X1/SvJ) or (involves 129S1/Sv * 129X1/SvJ * CD-1) J:96884
Nkx3-1tm1Hha/Nkx3-1+   involves: 129S4/SvJae * C57BL/6 J:63764
Nkx3-1tm1Hha/Nkx3-1tm1Hha   involves: 129S4/SvJae * C57BL/6 J:63764
Nkx3-1tm1Mms/Nkx3-1+   either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J) J:54465
Nkx3-1tm1Mms/Nkx3-1tm1Mms   either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J) J:54465
Models involving transgenes or other mutation types.3
Artm1(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		   involves: 129S1/Sv * C57BL/6 J:108849
Artm2(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		   involves: 129S1/Sv * C57BL/6 J:108849
Artm3(AR)Dmr/Y
Tg(TRAMP)8247Ng/0		   involves: 129S1/Sv * C57BL/6 J:108849
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(tetO-BRAF*V600E)29Lc/0
Tg(Tyr-rtTA)37Lc/0		   involves: 129/Sv * C57BL/6J * SJL J:144358
Ptentm1Hwu/Pten+
Tg(ARR2/Pbsn-FGF8)3Prb/0
Tg(Pbsn-cre)4Prb/0		 4 involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2 J:106650
Ptentm1Ppp/Pten+
Tg(Pbsn-TAg)15Tvd/0		   involves: 129S1/Sv * C57BL/6 * DBA/2 J:103408
Tg(CAG-SAC/EGFP)35Rang/0
Tg(TRAMP)8247Ng/0		   involves: C3H * C57BL/6 J:125633
Tg(Ggamma-T)15Cps/Tg(Ggamma-T)15Cps   involves: C57BL/6J * CBA/J J:38778
Tg(Ggamma-T)15Cps/0   involves: C57BL/6J * CBA/J J:38778
Tg(Msmb-TAg)183-2Xuan/0   involves: C57BL/6 * CBA J:80313
Tg(Msmb-TAg)186-3Xuan/0   involves: C57BL/6 * CBA J:80313
Tg(Pbsn-Ar*E231G)7353Ng/0   involves: FVB/N J:96117
Tg(Pbsn-IGF1*)5305Ng/0
Tg(TRAMP)8247Ng/0		   involves: C57BL/6 * FVB/N J:144539
Tg(Pbsn-MYC)6Key/?   involves: FVB J:85480
Tg(Pbsn-TAg)15Tvd/0   involves: C57BL/6 * DBA/2 J:103408
Tg(TRAMP)8247Ng/0   involves: C57BL/6 J:65303

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory