Human Disease and Mouse Model Detail

Human Disease

Term: Familial Adenomatous Polyposis 1; FAP1
OMIM ID: 175100

Synonyms

Adenomatous Polyposis of the Colon; APC; Familial Polyposis of the Colon; FPC

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Apc

APC

...both mouse and human orthologous genes.

Rab25

RAB25

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Apc^Min/Apc⁺		involves: AKR/J * C57BL/6J	J:830
Apc^Min/Apc⁺ Rab25^tm1Jrgo/Rab25^tm1Jrgo		B6.Cg-Rab25^tm1Jrgo Apc^Min	J:158733
Apc^tm1Mmt/Apc⁺		involves: 129S2/SvPas * C57BL/6J	J:25200
Apc^tm1Rak/Apc⁺		involves: 129P2/OlaHsd * C57BL/6	J:20443
Apc^tm1Tno/Apc^tm1Tno		involves: 129S4/SvJae * C57BL/6	J:43301

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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