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Human Disease and Mouse Model Detail
Human Disease

Term: Parkinson Disease 1, Autosomal Dominant; PARK1
OMIM ID: 168601

Synonyms Parkinson Disease 1, Autosomal Dominant Lewy Body
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Snca SNCA
  mousehuman...both mouse and human orthologous genes.
     
Transgenes and
other mutation types
Tg(PDGFB-SNCA)4Ema   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Prnp-SNCA*A53T)23Mkle
Tg(Prnp-SNCA*A53T)25Mkle
Tg(Prnp-SNCA*A53T)83Vle
Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm
Tg(SNCA*A53T)1Nbm
Tg(SNCA*A53T)2Nbm
Tg(SNCA)ARyot
Tg(Th-SNCA*)1702Yosh
Tg(Thy1-SNCA)61Ema
Tg(Thy1-SNCA*A30P)18Pjk

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
  involves: 129S6/SvEvTac * FVB/N J:156741
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm
Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
  involves: 129S6/SvEvTac * FVB/N J:156741
Sncatm1Rosl/Sncatm1Rosl   involves: 129X1/SvJ * C57BL/6 J:60151
Models with phenotypic similarity to human disease where etiologies are distinct.2
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
4 involves: 129 * C57BL/6 * SJL J:150777
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
4 involves: 129 * C57BL/6 J:150777
Models involving transgenes or other mutation types.3
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
  involves: 129S6/SvEvTac * FVB/N J:156741
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm
Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
  involves: 129S6/SvEvTac * FVB/N J:156741
Tg(PDGFB-SNCA)4Ema/0   involves: C57BL/6 * DBA/2 J:60638, J:166985
Tg(Prnp-SNCA*A53T)23Mkle/0   involves: C3H/HeJ * C57BL/6J J:77344
Tg(Prnp-SNCA*A53T)25Mkle/0   involves: C3H/HeJ * C57BL/6J J:77344
Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle   involves: C3H * C57BL/6 J:76657
Tg(Prnp-SNCA*A53T)83Vle/0   involves: C3H * C57BL/6 J:76657
Tg(SNCA)ARyot/0   C57BL/6J-Tg(SNCA)ARyot J:185434
Tg(Th-SNCA*)1702Yosh/0   involves: C3H * C57BL/6J J:125149
Tg(Thy1-SNCA)61Ema/0   involves: C57BL/6 * DBA/2 J:137490
Tg(Thy1-SNCA*A30P)18Pjk/Tg(Thy1-SNCA*A30P)18Pjk   involves: C57BL/6 J:80181

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory