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Human Disease and Mouse Model Detail
Human Disease

Term: Parkinson Disease, Late-Onset; PD
OMIM ID: 168600

Synonyms Park
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Adh7 ADH7
Atg7 ATG7
En1 EN1
Mfn2 MFN2
Slc6a3 SLC6A3
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Adh1 ADH1C
Gba GBA
Mapt MAPT
Nr4a2 NR4A2
Sncaip SNCAIP
Tbp TBP
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(CAG-SNCA*)1.1Ccs   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(GFAP-tTA)#Hyms
Tg(tetO-COX8A/PstI*)1Ctm
Tg(tetO-HMOX1)#Hyms
Tg(Th-SNCA*)1.2Ccs

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Adh7tm1Gdu/Adh7tm1Gdu   B6.129-Adh7tm1Gdu J:167234
Atg7tm1Tchi/Atg7tm1Tchi
Slc6a3tm1(cre)Xz/Slc6a3+
3 involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj J:192452
Atg7tm1Tchi/Atg7tm1Tchi
En1tm2(cre)Wrst/En1+
3 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj J:192452
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Mfn2tm3Dcc/Mfn2tm3Dcc
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
3 involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J J:188347
Slc6a3tm2(tTA)Xz/Slc6a3+
Tg(tetO-COX8A/PstI*)1Ctm/0
  involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL J:178139
Models involving transgenes or other mutation types.2
Slc6a3tm2(tTA)Xz/Slc6a3+
Tg(tetO-COX8A/PstI*)1Ctm/0
  involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL J:178139
Tg(CAG-SNCA*)1.1Ccs/?   involves: C57BL/6 J:168847
Tg(GFAP-tTA)#Hyms/0
Tg(tetO-HMOX1)#Hyms/0
  involves: FVB J:190573
Tg(Th-SNCA*)1.2Ccs/?   involves: C57BL/6 J:168847

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.
3Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory