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Human Disease and Mouse Model Detail
Human Disease

Term: Ovarian Cancer
OMIM ID: 167000

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Ctnnb1 CTNNB1
  mousehuman...both mouse and human orthologous genes.
     
Amhr2 AMHR2
Kras KRAS
Pten PTEN
Rb1 RB1
Smad1 SMAD1
Smad5 SMAD5
Trp53 TP53
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Akt1 AKT1
Cdh1 CDH1
Opcml OPCML
Park2 PARK2
Pik3ca PIK3CA
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Amhr2-SV40TAg)1Dcco   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(CAG-lacZ,-SV40)#Bcv

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
5 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 J:186144
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
5 involves: 129X1/SvJ * C57BL/6 J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
5 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
5 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Tg(CYP19A1-cre)1Jri/0
5 involves: 129X1/SvJ * C57BL/6 J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Amhr2tm3(cre)Bhr/Amhr2+
5 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 J:186144
Models with phenotypic similarity to human disease where etiologies are distinct.2
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
5 involves: 129S5/SvEvBrd * C57BL/6J J:157310
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2.1Rob
Smad5tm1Huy/Smad5tm1Huy
5 involves: 129S5/SvEvBrd * C57BL/6J J:157310
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Huy
5 involves: 129S5/SvEvBrd * C57BL/6J J:157310
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
5 involves: 129S4/SvJae * C57BL/6J J:96296
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
5 involves: 129S4/SvJae J:161953
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
5 involves: 129P2/OlaHsd J:84345
Models involving transgenes or other mutation types.3
Tg(Amhr2-SV40TAg)1Dcco/0   (C57BL/6 x C3H)F1 J:82550
Tg(CAG-lacZ,-SV40)#Bcv/0 5 involves: FVB/N J:158388
No similarity to the expected human disease phenotype was found.4
NOT Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0   involves: C3H * C57BL/6 J:144834

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.
5Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory