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Human Disease and Mouse Model Detail
Human Disease

Term: Otitis Media, Susceptibility to
OMIM ID: 166760

Synonyms COME/ROM; OMS; Otitis Media, Chronic/Recurrent
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Cby1 CBY1
Ctnnb1 CTNNB1
Dnahc5 DNAH5
E2f4 E2F4
Eya4 EYA4
Fbxo11 FBXO11
Fgfr1 FGFR1
Idua IDUA
Mecom MECOM
Naglu NAGLU
Nf2 NF2
Phex PHEX
Rpl38 RPL38
Sall4 SALL4
Sh3pxd2b SH3PXD2B
Tbx1 TBX1
Trp73 TP73
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.1
Cby1tm1Ktkm/Cby1tm1Ktkm   B6.129-Cby1tm1Ktkm J:147413
Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1+   involves: 129P2/OlaHsd * C57BL/6 J:71744
Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1+
Tg(CMV-cre)1Cgn/0		 2 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 J:71744
Dnahc5Tg1Htz/Dnahc5Tg1Htz   involves: C57BL/6 * CBA/J J:76189
E2f4tm1Lees/E2f4tm1Lees   involves: 129S2/SvPas * C57BL/6 J:64193
Eya4tm1Jse/Eya4tm1Jse   involves: 129S6/SvEvTac * CBA/J J:131873
Fbxo11Jf/Fbxo11+   involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J J:114851
Fbxo11Jf/Fbxo11Mutt   involves: BALB/c * C3H/HeN J:114851
Fgfr1Hspy/Fgfr1+   C3HeB/FeJ-Hspy J:95895
Iduatm1Efn/Iduatm1Efn   involves: C57BL/6 J:123676
MecomJbo/Mecom+   C3N.C-MecomJbo J:113445
Naglutm1Efn/Naglutm1Efn   involves: 129S/SvEv * C57BL/6J J:129390
Nf2tm1Gth/Nf2tm2Gth
Tg(P0-Cre)2Gth/0		 2 involves: 129P2/OlaHsd * FVB/N J:63264
Nf2tm2Gth/Nf2tm2Gth
Tg(P0-Cre)1Gth/0		 2 involves: 129P2/OlaHsd * FVB/N J:63264
Nf2tm2Gth/Nf2tm2Gth
Tg(P0-Cre)2Gth/0		 2 involves: 129P2/OlaHsd * FVB/N J:63264
PhexHyp-Duk/Y   involves: BALB/cAnBomUrd J:88352
Rpl38Ts/Rpl38+   TSJ/Le J:168509
Sall4tm1Brd/Sall4+   involves: 129S7/SvEvBrd * C57BL/6J J:117866
Sh3pxd2bnee/Sh3pxd2bnee   B10.Cg-H2h4 Sh3pxd2bnee/GrsrJ J:153369
Tbx1tm1Rak/Tbx1+   FVB.Cg-Tbx1tm1Rak J:91664
Trp73tm1Fmc/Trp73tm1Fmc   involves: 129S4/SvJae J:60896

1The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
2Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory