Human Disease and Mouse Model Detail

Human Disease

Term: Obsessive-Compulsive Disorder; OCD
OMIM ID: 164230

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Cyp19a1	CYP19A1
Dlgap3	DLGAP3
Slc6a3	SLC6A3
Slitrk5	SLITRK5

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Bdnf	BDNF
Htr2a	HTR2A
Slc6a4	SLC6A4

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Transgenes and
other mutation types

Tg(DRD1-ctxA)7Burt

Characteristics of this human disease are associated with transgenes and other mutation types in mouse.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Cyp19a1^tm1Esi/Cyp19a1^tm1Esi		involves: 129S6/SvEvTac * C57BL/6J	J:129528
Dlgap3^tm1Gfng/Dlgap3^tm1Gfng		Not Specified	J:125181
Slc6a3^tm2Mca/Slc6a3^tm2Mca		involves: 129S1/Sv * 129X1/SvJ	J:176799
Slitrk5^tm2Vlcg/Slitrk5^tm2Vlcg		involves: 129S/Sv * C57BL/6	J:160616
Models involving transgenes or other mutation types.²
Tg(DRD1-ctxA)7Burt/0		C.Cg-Tg(DRD1-ctxA)7Burt	J:133268, J:133402

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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