Human Disease and Mouse Model Detail

Human Disease

Term: Mesothelioma, Malignant; MESOM
OMIM ID: 156240

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Cdkn2a	CDKN2A
Nf2	NF2
Trp53	TP53

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Bcl10	BCL10
Wt1	WT1

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Nf2^tm2Gth/Nf2^tm2Gth Trp53^tm1Brn/Trp53^tm1Brn	2	involves: 129P2/OlaHsd * 129S7/SvEvBrd	J:132943
Cdkn2a^tm1.1Brn/Cdkn2a⁺ Nf2^tm2Gth/Nf2^tm2Gth Trp53^tm1Brn/Trp53^tm1Brn	2	involves: 129P2/OlaHsd * 129S7/SvEvBrd	J:132943
Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Nf2^tm2Gth/Nf2^tm2Gth	2	involves: 129P2/OlaHsd	J:132943
Nf2^tm2Gth/Nf2^tm2Gth Trp53^tm1Brn/Trp53^tm1Brn	2	involves: 129P2/OlaHsd * 129S7/SvEvBrd	J:132943

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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